PF-06821497 is a potent and selective EZH2 inhibitor. Upon oral administration, EZH2 inhibitor PF-06821497 selectively targets, binds to and inhibits the activity of EZH2. Inhibition of EZH2 specifically prevents the methylation of histone H3 on lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated with cancer pathways and results in decreased proliferation of EZH2-expressing cancer cells.
MedKoo Cat#: 206825
Name: PF-06821497
CAS#: 1844849-10-1
Chemical Formula: C22H24Cl2N2O5
Exact Mass: 466.1062
Molecular Weight: 467.34
Elemental Analysis: C, 56.54; H, 5.18; Cl, 15.17; N, 5.99; O, 17.12
The following data is based on the product molecular weight 467.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
