Synonym
MMAD; Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10
IUPAC/Chemical Name
(S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
InChi Key
BLUGYPPOFIHFJS-UUFHNPECSA-N
InChi Code
InChI=1S/C41H66N6O6S/c1-12-27(6)36(46(9)41(51)35(26(4)5)45-39(50)34(42-8)25(2)3)32(52-10)24-33(48)47-21-16-19-31(47)37(53-11)28(7)38(49)44-30(40-43-20-22-54-40)23-29-17-14-13-15-18-29/h13-15,17-18,20,22,25-28,30-32,34-37,42H,12,16,19,21,23-24H2,1-11H3,(H,44,49)(H,45,50)/t27-,28+,30-,31-,32+,34-,35-,36-,37+/m0/s1
SMILES Code
O=C(N[C@@H](CC1=CC=CC=C1)C2=NC=CS2)[C@H](C)[C@H]([C@@]3(CCCN3C(C[C@H]([C@H]([C@H](CC)C)N(C([C@H](C(C)C)NC([C@@H](N(C)[H])C(C)C)=O)=O)C)OC)=O)[H])OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
771.08
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dorywalska M, Strop P, Melton-Witt JA, Hasa-Moreno A, Farias SE, Galindo Casas
M, Delaria K, Lui V, Poulsen K, Sutton J, Bolton G, Zhou D, Moine L, Dushin R,
Tran TT, Liu SH, Rickert M, Foletti D, Shelton DL, Pons J, Rajpal A.
Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in
Rodent Plasma and Its Effect on ADC Efficacy. PLoS One. 2015 Jul
10;10(7):e0132282. doi: 10.1371/journal.pone.0132282. eCollection 2015. PubMed
PMID: 26161543; PubMed Central PMCID: PMC4498778.
