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MedKoo Cat#: 206812 | Name: Emicoron

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Emicoron is a multi-targeting G4 ligand. Emicoron showed Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer. EMICORON showed a marked therapeutic efficacy, as it inhibited the growth of patient-derived xenografts (PDX) and orthotopic colon cancer and strongly reduced the dissemination of tumor cells to lymph nodes, intestine, stomach, and liver. EMICORON had an unprecedented antitumor activity warranting further studies of EMICORON-based combination treatments.

Chemical Structure

Emicoron
Emicoron
CAS#1422423-23-1

Theoretical Analysis

MedKoo Cat#: 206812

Name: Emicoron

CAS#: 1422423-23-1

Chemical Formula: C52H58N6O4

Exact Mass: 830.4520

Molecular Weight: 831.07

Elemental Analysis: C, 75.15; H, 7.03; N, 10.11; O, 7.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Emicoron
IUPAC/Chemical Name
13-(piperidin-1-yl)-2,5,9-tris(2-(piperidin-1-yl)ethyl)pyreno[2,1,10-def:7,8,9-d'e'f']diisoquinoline-1,3,8,10(2H,9H)-tetraone
InChi Key
VRQVIIJBMWLLKQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C52H58N6O4/c59-49-36-14-13-35-45-41(56-22-11-4-12-23-56)32-40-44-39(51(61)58(52(40)62)28-26-55-20-9-3-10-21-55)31-37-33(15-24-53-16-5-1-6-17-53)29-34-30-38(43(36)46(35)42(34)47(37)48(44)45)50(60)57(49)27-25-54-18-7-2-8-19-54/h13-14,29-32H,1-12,15-28H2
SMILES Code
O=C(C(C=C1)=C2C3=C1C4=C(N5CCCCC5)C=C(C(N6CCN7CCCCC7)=O)C8=C4C(C3=C9C=C2%10)=C(C(CCN%11CCCCC%11)=C9)C=C8C6=O)N(CCN%12CCCCC%12)C%10=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 831.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Porru M, Artuso S, Salvati E, Bianco A, Franceschin M, Diodoro MG, Passeri D, Orlandi A, Savorani F, D'Incalci M, Biroccio A, Leonetti C. Targeting G-Quadruplex DNA Structures by EMICORON Has a Strong Antitumor Efficacy against Advanced Models of Human Colon Cancer. Mol Cancer Ther. 2015 Nov;14(11):2541-51. doi: 10.1158/1535-7163.MCT-15-0253. Epub 2015 Aug 24. PubMed PMID: 26304235. 2: Porru M, Zizza P, Franceschin M, Leonetti C, Biroccio A. EMICORON: A multi-targeting G4 ligand with a promising preclinical profile. Biochim Biophys Acta. 2016 Nov 9. pii: S0304-4165(16)30413-5. doi: 10.1016/j.bbagen.2016.11.010. [Epub ahead of print] PubMed PMID: 27838395. 3: Franceschin M, Rizzo A, Casagrande V, Salvati E, Alvino A, Altieri A, Ciammaichella A, Iachettini S, Leonetti C, Ortaggi G, Porru M, Bianco A, Biroccio A. Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells. ChemMedChem. 2012 Dec;7(12):2144-54. doi: 10.1002/cmdc.201200348. Epub 2012 Oct 24. PubMed PMID: 23097341. 4: Micheli E, Altieri A, Cianni L, Cingolani C, Iachettini S, Bianco A, Leonetti C, Cacchione S, Biroccio A, Franceschin M, Rizzo A. Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells. Biochimie. 2016 Jun;125:223-31. doi: 10.1016/j.biochi.2016.04.008. Epub 2016 Apr 13. PubMed PMID: 27086081.