Synonym
BW-1370U87; BW 1370U87; BW1370U87; 1370U-87; 1370U 87; 1370U87
IUPAC/Chemical Name
1-ethylphenoxathiine 10,10-dioxide
InChi Key
HQSRQKBSOOZLHH-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H12O3S/c1-2-10-6-5-8-12-14(10)18(15,16)13-9-4-3-7-11(13)17-12/h3-9H,2H2,1H3
SMILES Code
CCC(C=CC=C1OC2=C3C=CC=C2)=C1S3(=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
260.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Harfenist M, McGee DP, Reeves MD, White HL. Selective inhibitors of monoamine oxidase (MAO). 5. 1-Substituted phenoxathiin inhibitors containing no nitrogen that inhibit MAO A by binding it to a hydrophobic site. J Med Chem. 1998 Jun 4;41(12):2118-25. PubMed PMID: 9622553.
2: Shockcor JP, Silver IS, Wurm RM, Sanderson PN, Farrant RD, Sweatman BC, Lindon JC. Characterization of in vitro metabolites from human liver microsomes using directly coupled hplc-nmr: application to a phenoxathiin monoamine oxidase-A inhibitor. Xenobiotica. 1996 Jan;26(1):41-8. PubMed PMID: 8851820.
3: Taylor LC, Johnson RL, St John-Williams L, Johnson T, Chang SY. The use of low-energy collisionally activated dissociation negative-ion tandem mass spectrometry for the characterization of dog and human urinary metabolites of the drug BW 1370U87. Rapid Commun Mass Spectrom. 1994 Mar;8(3):265-73. PubMed PMID: 8167371.
4: White HL, Ascher JA. Preclinical and early clinical studies with BW 1370U87, a reversible competitive monoamine oxidase-A inhibitor. Clin Neuropharmacol. 1993;16 Suppl 2:S25-33. Review. PubMed PMID: 8313394.
5: White HL, Ascher JA. Preclinical and early clinical studies with BW 1370U87, a reversible competitive MAO-A inhibitor. Clin Neuropharmacol. 1992;15 Suppl 1 Pt A:343A-344A. PubMed PMID: 1354041.
