CS-2100 is a potent, orally active and S1P3-sparing S1P1 agonist. CS-2100 had >5000-fold greater agonist activity for human S1P(1) (EC(50); 4.0 nM) relative to S1P(3) (EC(50); >20,000 nM). CS-2100 is efficacious in the adjuvant-induced arthritis model in rats (ID(50); 0.44 mg/kg). CS-2100 showed potent efficacy in various animal disease models, it was also revealed that the central 1,2,4-oxadiazole ring of CS-2100 was decomposed by enterobacteria in intestine of rats and monkeys, implicating the latent concern about an external susceptibility in its metabolic process in the upcoming clinical studies.
MedKoo Cat#: 530563
Name: CS-2100
CAS#: 913827-99-3
Chemical Formula: C25H23N3O4S
Exact Mass: 461.1409
Molecular Weight: 461.54
Elemental Analysis: C, 65.06; H, 5.02; N, 9.10; O, 13.87; S, 6.95
The following data is based on the product molecular weight 461.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
