Napamezole | WIN-51181 | CAS#91524-14-0 | α2 Adrenergic Receptor Antagonist

MedKoo Cat#: 528510 | Name: Napamezole

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Napamezole, also known as WIN-51181, is an α2 adrenergic receptor antagonist potentially for the treatment of major depressive disorder and anxiety. Napamezole reversed clonidine-induced decreased in twitch height in the electrically stimulated rat vas deferens. Napamezole also antagonized methoxamine-induced contractions (alpha-1) of the rat vas deferens with a Kb of 135 nM.

Chemical Structure

Napamezole

CAS#91524-14-0

Theoretical Analysis

MedKoo Cat#: 528510

Name: Napamezole

CAS#: 91524-14-0

Chemical Formula: C14H16N2

Exact Mass: 212.1313

Molecular Weight: 212.30

Elemental Analysis: C, 79.21; H, 7.60; N, 13.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Napamezole; WIN-51181; WIN 51181; WIN51181

IUPAC/Chemical Name

2-((3,4-dihydronaphthalen-2-yl)methyl)-4,5-dihydro-1H-imidazole

InChi Key

WETRBJOSGIDJHQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H16N2/c1-2-4-13-9-11(5-6-12(13)3-1)10-14-15-7-8-16-14/h1-4,9H,5-8,10H2,(H,15,16)

SMILES Code

C1(CC2=CC3=C(C=CC=C3)CC2)=NCCN1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 212.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cordi AA, Berque-Bestel I, Persigand T, Lacoste JM, Newman-Tancredi A, Audinot V, Millan MJ. Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties. J Med Chem. 2001 Mar 1;44(5):787-805. PubMed PMID: 11262089. 2: Perrone MH, Luttinger D, Hamel LT, Fritz PM, Ferraino R, Haubrich DR. In vivo assessment of napamezole, an alpha-2 adrenoceptor antagonist and monoamine re-uptake inhibitor. J Pharmacol Exp Ther. 1990 Aug;254(2):476-83. PubMed PMID: 1974638. 3: Perrone MH, Hamel LT, Ferrari RA, Haubrich DR. Napamezole, an alpha-2 adrenergic receptor antagonist and monoamine uptake inhibitor in vitro. J Pharmacol Exp Ther. 1990 Aug;254(2):471-5. PubMed PMID: 1974637. 4: Wentland MP, Bailey DM, Alexander EJ, Castaldi MJ, Ferrari RA, Haubrich DR, Luttinger DA, Perrone MH. Synthesis and antidepressant properties of novel 2-substituted 4,5-dihydro-1H-imidazole derivatives. J Med Chem. 1987 Aug;30(8):1482-9. PubMed PMID: 3039138.