Trazium esilate, also known as EGYT-3615, is an adrenergic receptor antagonist potentially for the treatment of major depressive disorder. Trazium esilate is a weak displacer on a1-, a2- and D2-receptors, however, it induced a2-receptor desenzitization after repeated treatment. It had no influence on rat brain cortical noradrenaline and striatal dopamine release evoked by high K+ concentration, but it increased the spontaneous dopamine outflow in rat striatum.
MedKoo Cat#: 528509
Name: Trazium Esilate
CAS#: 97110-59-3
Chemical Formula: C19H18ClN3O4S
Exact Mass:
Molecular Weight: 419.88
Elemental Analysis: C, 54.35; H, 4.32; Cl, 8.44; N, 10.01; O, 15.24; S, 7.64
The following data is based on the product molecular weight 419.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
