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MedKoo Cat#: 532286 | Name: MRS2279

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MRS2279 is a selective and competitive antagonist of the P2Y1 receptor (Ki = 2.5 nM; IC50 = 51.6 nM). MRS2279 potently inhibits ADP-induced aggregation of human blood platelets in vitro (pKB = 8.05).

Chemical Structure

MRS2279
MRS2279
CAS#367909-40-8

Theoretical Analysis

MedKoo Cat#: 532286

Name: MRS2279

CAS#: 367909-40-8

Chemical Formula: C13H20ClN5O8P2

Exact Mass: 471.0500

Molecular Weight: 471.73

Elemental Analysis: C, 33.10; H, 4.27; Cl, 7.51; N, 14.85; O, 27.13; P, 13.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MRS2279; MRS-2279; MRS 2279.
IUPAC/Chemical Name
[(1S,2R,4R)-4-[(2-chloro-6-methylaminopurin-9-yl)methyl]-2-(phosphonooxymethyl)cyclopentyl] dihydrogen phosphate
InChi Key
LPZJKPSGEADHTQ-HLTSFMKQSA-N
InChi Code
InChI=1S/C13H20ClN5O8P2/c1-15-11-10-12(18-13(14)17-11)19(6-16-10)4-7-2-8(5-26-28(20,21)22)9(3-7)27-29(23,24)25/h6-9H,2-5H2,1H3,(H,15,17,18)(H2,20,21,22)(H2,23,24,25)/t7-,8-,9+/m1/s1
SMILES Code
O=P(O)(O[C@@H]1[C@@H](COP(O)(O)=O)C[C@@H](CN2C=NC3=C(NC)N=C(Cl)N=C23)C1)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 471.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Khan S, Yan-Do R, Duong E, Wu X, Bautista A, Cheley S, MacDonald PE, Braun M. Autocrine activation of P2Y1 receptors couples Ca (2+) influx to Ca (2+) release in human pancreatic beta cells. Diabetologia. 2014 Dec;57(12):2535-45. doi: 10.1007/s00125-014-3368-8. Epub 2014 Sep 11. PubMed PMID: 25208758. 2: Huang J, Zhang M, Zhang P, Liang H, Ouyang K, Yang HT. Coupling switch of P2Y-IP3 receptors mediates differential Ca(2+) signaling in human embryonic stem cells and derived cardiovascular progenitor cells. Purinergic Signal. 2016 Sep;12(3):465-78. doi: 10.1007/s11302-016-9512-9. Epub 2016 Apr 20. PubMed PMID: 27098757; PubMed Central PMCID: PMC5023627. 3: Tanaka S, Kudo H, Asari T, Ono A, Motomura S, Toh S, Furukawa K. P2Y1 transient overexpression induced mineralization in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament of the cervical spine. Calcif Tissue Int. 2011 Apr;88(4):263-71. doi: 10.1007/s00223-010-9456-y. Epub 2011 Jan 6. PubMed PMID: 21210088.