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MedKoo Cat#: 528811 | Name: CR-4056

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CR-4056 is an imidazoneuline I2 receptor ligand potentially for treatment of neuropathic pain.

Chemical Structure

CR-4056
CR-4056
CAS#1004997-71-0

Theoretical Analysis

MedKoo Cat#: 528811

Name: CR-4056

CAS#: 1004997-71-0

Chemical Formula: C17H12N4

Exact Mass: 272.1062

Molecular Weight: 272.31

Elemental Analysis: C, 74.98; H, 4.44; N, 20.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CR-4056; CR4056; CR 4056
IUPAC/Chemical Name
6-(1H-imidazol-1-yl)-2-phenylquinazoline
InChi Key
CSZGXYBGYFNSCO-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H12N4/c1-2-4-13(5-3-1)17-19-11-14-10-15(6-7-16(14)20-17)21-9-8-18-12-21/h1-12H
SMILES Code
C1(C2=CC=CC=C2)=NC=C3C=C(N4C=CN=C4)C=CC3=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 272.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Qiu Y, He XH, Zhang Y, Li JX. Discriminative stimulus effects of the novel imidazoline I₂ receptor ligand CR4056 in rats. Sci Rep. 2014 Oct 13;4:6605. doi: 10.1038/srep06605. PubMed PMID: 25308382; PubMed Central PMCID: PMC4194429. 2: Lanza M, Ferrari F, Menghetti I, Tremolada D, Caselli G. Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats. Br J Pharmacol. 2014 Aug;171(15):3693-701. doi: 10.1111/bph.12728. PubMed PMID: 24758515; PubMed Central PMCID: PMC4128066. 3: Ferrari F, Fiorentino S, Mennuni L, Garofalo P, Letari O, Mandelli S, Giordani A, Lanza M, Caselli G. Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain. J Pain Res. 2011;4:111-25. doi: 10.2147/JPR.S18353. Epub 2011 Apr 18. PubMed PMID: 21647215; PubMed Central PMCID: PMC3100226. 4: Li JX, Thorn DA, Qiu Y, Peng BW, Zhang Y. Antihyperalgesic effects of imidazoline I(2) receptor ligands in rat models of inflammatory and neuropathic pain. Br J Pharmacol. 2014 Mar;171(6):1580-90. doi: 10.1111/bph.12555. PubMed PMID: 24329196; PubMed Central PMCID: PMC3954494. 5: Meregalli C, Ceresa C, Canta A, Carozzi VA, Chiorazzi A, Sala B, Oggioni N, Lanza M, Letari O, Ferrari F, Avezza F, Marmiroli P, Caselli G, Cavaletti G. CR4056, a new analgesic I2 ligand, is highly effective against bortezomib-induced painful neuropathy in rats. J Pain Res. 2012;5:151-67. doi: 10.2147/JPR.S32122. Epub 2012 Jun 20. PubMed PMID: 22792002; PubMed Central PMCID: PMC3392714. 6: Qiu Y, Zhang Y, Li JX. Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats. Eur J Pharmacol. 2015 Feb 15;749:133-41. doi: 10.1016/j.ejphar.2015.01.013. Epub 2015 Jan 21. PubMed PMID: 25617792; PubMed Central PMCID: PMC4331254. 7: Thorn DA, An XF, Zhang Y, Pigini M, Li JX. Characterization of the hypothermic effects of imidazoline I₂ receptor agonists in rats. Br J Pharmacol. 2012 Jul;166(6):1936-45. doi: 10.1111/j.1476-5381.2012.01894.x. PubMed PMID: 22324428; PubMed Central PMCID: PMC3402816. 8: Thorn DA, Zhang Y, Li JX. Effects of the imidazoline I2 receptor agonist 2-BFI on the development of tolerance to and behavioural/physical dependence on morphine in rats. Br J Pharmacol. 2016 Apr;173(8):1363-72. doi: 10.1111/bph.13435. Epub 2016 Feb 25. PubMed PMID: 26776953; PubMed Central PMCID: PMC4940811. 9: Thorn DA, Qiu Y, Jia S, Zhang Y, Li JX. Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats. Behav Pharmacol. 2016 Jun;27(4):377-83. doi: 10.1097/FBP.0000000000000206. PubMed PMID: 26599907; PubMed Central PMCID: PMC4842102. 10: Li JX. Imidazoline I(2) receptors: An update. Pharmacol Ther. 2017 Mar 16. pii: S0163-7258(17)30089-X. doi: 10.1016/j.pharmthera.2017.03.009. [Epub ahead of print] Review. PubMed PMID: 28322973.

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