Synonym
NOX-100; NOX100; NOX 100
IUPAC/Chemical Name
sodium methyl((2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl)carbamodithioate
InChi Key
PLQRBFAACWRSKF-LJTMIZJLSA-M
InChi Code
InChI=1S/C8H17NO5S2.Na/c1-9(8(15)16)2-4(11)6(13)7(14)5(12)3-10;/h4-7,10-14H,2-3H2,1H3,(H,15,16);/q;+1/p-1/t4-,5+,6+,7+;/m0./s1
SMILES Code
O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CN(C([S-])=S)C.[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
293.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sato M, Ohtsuka T, Stell WK. Endogenous nitric oxide enhances the light-response of cones during light-adaptation in the rat retina. Vision Res. 2011 Jan;51(1):131-7. doi: 10.1016/j.visres.2010.10.011. PubMed PMID: 20951158.
2: Mihailovic-Stanojevic N, Belščak-Cvitanović A, Grujić-Milanović J, Ivanov M, Jovović Dj, Bugarski D, Miloradović Z. Antioxidant and antihypertensive activity of extract from Thymus serpyllum L. in experimental hypertension. Plant Foods Hum Nutr. 2013 Sep;68(3):235-40. doi: 10.1007/s11130-013-0368-7. PubMed PMID: 23828496.
3: Nadler EP, Dickinson EC, Beer-Stolz D, Alber SM, Watkins SC, Pratt DW, Ford HR. Scavenging nitric oxide reduces hepatocellular injury after endotoxin challenge. Am J Physiol Gastrointest Liver Physiol. 2001 Jul;281(1):G173-81. PubMed PMID: 11408270.
4: Roza AM, Cooper M, Pieper G, Hilton G, Dembny K, Lai CS, Lindholm P, Komorowski R, Felix C, Johnson C, Adams M. NOX 100, a nitric oxide scavenger, enhances cardiac allograft survival and promotes long-term graft acceptance. Transplantation. 2000 Jan 27;69(2):227-31. PubMed PMID: 10670631.
5: Hierholzer C, Billiar TR, Tweardy DJ, Harbrecht B. Reduced hepatic transcription factor activation and expression of IL-6 and ICAM-1 after hemorrhage by NO scavenging. Arch Orthop Trauma Surg. 2003 Apr;123(2-3):55-9. PubMed PMID: 12721681.
6: Kagota S, Yamaguchi Y, Nakamura K, Shinozuka K, Kunitomo M. Chronic nitric oxide exposure alters the balance between endothelium-derived relaxing factors released from rat renal arteries: prevention by treatment with NOX-100, a NO scavenger. Life Sci. 2004 Apr 16;74(22):2757-67. PubMed PMID: 15043990.
