MedKoo Cat#: 530552 | Name: CP-424174
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-424174 is a cytokine release inhibitory drug (CRID) (IC50 = 210 nM).CP-424174 inhibits the post-translational processing and secretion of IL-1b in response to LPS and ATP in human monocytes.

Chemical Structure

CP-424174
CP-424174
CAS#210825-31-3

Theoretical Analysis

MedKoo Cat#: 530552

Name: CP-424174

CAS#: 210825-31-3

Chemical Formula: C22H29ClN2O4S

Exact Mass: 452.1537

Molecular Weight: 452.99

Elemental Analysis: C, 58.33; H, 6.45; Cl, 7.83; N, 6.18; O, 14.13; S, 7.08

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
CP-424174; CP 424174; CP424174; CP-424,174; CP 424,174; CP424,174.
IUPAC/Chemical Name
N-[[[4-Chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-3-(1-hydroxy-1-methylethyl)benzenesulfonamide
InChi Key
YRSBLSHMKVQWHP-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H29ClN2O4S/c1-13(2)18-11-16(23)12-19(14(3)4)20(18)24-21(26)25-30(28,29)17-9-7-8-15(10-17)22(5,6)27/h7-14,27H,1-6H3,(H2,24,25,26)
SMILES Code
O=S(C1=CC=CC(C(C)(O)C)=C1)(NC(NC2=C(C(C)C)C=C(Cl)C=C2C(C)C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 452.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Perregaux DG, McNiff P, Laliberte R, Hawryluk N, Peurano H, Stam E, Eggler J, Griffiths R, Dombroski MA, Gabel CA. Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors. J Pharmacol Exp Ther. 2001 Oct;299(1):187-97. PubMed PMID: 11561079. 2: Perregaux DG, Bhavsar K, Contillo L, Shi J, Gabel CA. Antimicrobial peptides initiate IL-1 beta posttranslational processing: a novel role beyond innate immunity. J Immunol. 2002 Mar 15;168(6):3024-32. PubMed PMID: 11884475.