MM 11253 | CAS# 345952-44-5 |RARγ antagonist |MedKoo

MedKoo Cat#: 532255 | Name: MM 11253

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MM 11253 is a selective RARγ antagonist. MM 11253 blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells.

Chemical Structure

MM 11253

CAS#345952-44-5

Theoretical Analysis

MedKoo Cat#: 532255

Name: MM 11253

CAS#: 345952-44-5

Chemical Formula: C28H30O2S2

Exact Mass: 462.1687

Molecular Weight: 462.67

Elemental Analysis: C, 72.69; H, 6.54; O, 6.92; S, 13.86

Price and Availability

Size	Price	Availability
5mg	USD 250.00	2 weeks
10mg	USD 450.00	2 weeks
25mg	USD 850.00	2 weeks

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Related CAS #

No Data

Synonym

MM 11253; MM-11253; MM11253.

IUPAC/Chemical Name

6-[2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid

InChi Key

DPVGXUNWCVEIGT-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H30O2S2/c1-26(2)11-12-27(3,4)24-17-22(9-10-23(24)26)28(31-13-14-32-28)21-8-7-18-15-20(25(29)30)6-5-19(18)16-21/h5-10,15-17H,11-14H2,1-4H3,(H,29,30)

SMILES Code

O=C(C1=CC=C2C=C(C3(C4=CC=C5C(C)(C)CCC(C)(C)C5=C4)SCCS3)C=CC2=C1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

MM 11253 is a selective RARγ antagonist.

In vitro activity:

This study found that oral SCC (squamous cell carcinoma) cells exhibiting reduced RAR/RXR function became resistant to growth inhibition by all-trans-RA, MM11254 and MM11389. Likewise, treatment of oral SCC cells with the RARgamma antagonist MM11253 was found to block the ability of MM11254 and MM11389 to inhibit SCC cell growth. Reference: Oncogene. 2000 Mar 9;19(11):1457-65. https://pubmed.ncbi.nlm.nih.gov/10723137/

In vivo activity:

TBD

	Solvent	mg/mL	mM	comments
Solubility
	DMSO	38.1	82.42

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 462.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Le Q, Dawson MI, Soprano DR, Soprano KJ. Modulation of retinoic acid receptor function alters the growth inhibitory response of oral SCC cells to retinoids. Oncogene. 2000 Mar 9;19(11):1457-65. doi: 10.1038/sj.onc.1203436. PMID: 10723137.

In vitro protocol:

In vivo protocol:

TBD

1: Holmes WF, Dawson MI, Soprano RD, Soprano KJ. Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors. J Cell Physiol. 2000 Oct;185(1):61-7. PubMed PMID: 10942519.