LY 334370 hydrochloride | CAS#199673-74-0 |182563-08-2 | 5-HT1F receptor agonist

MedKoo Cat#: 532161 | Name: LY 334370 hydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY 334370 hydrochloride is a selective 5-HT1F receptor agonist (Ki values are 1.87, 16.4, > 100 (IC50)). LY 334370 hydrochloride displays antimigraine effects.

Chemical Structure

LY 334370 hydrochloride

CAS#199673-74-0

Theoretical Analysis

MedKoo Cat#: 532161

Name: LY 334370 hydrochloride

CAS#: 199673-74-0

Chemical Formula: C21H23ClFN3O

Exact Mass: 0.0000

Molecular Weight: 387.88

Elemental Analysis: C, 65.03; H, 5.98; Cl, 9.14; F, 4.90; N, 10.83; O, 4.12

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 350.00	2 weeks
50mg	USD 950.00	2 weeks

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Related CAS #

199673-74-0(LY 334370 hydrochloride); 182563-08-2 (LY 334370 Free Base).

Synonym

LY 334370 hydrochloride; LY 334370 HCl; LY 334370; LY-334370; LY334370.

IUPAC/Chemical Name

4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride

InChi Key

DGPDGAPZTPSHBL-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H22FN3O.ClH/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15;/h2-7,12-14,23H,8-11H2,1H3,(H,24,26);1H

SMILES Code

O=C(NC1=CC2=C(NC=C2C3CCN(C)CC3)C=C1)C4=CC=C(F)C=C4.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

LY 334370 hydrochloride is a selective 5-HT1F receptor agonist.

In vitro activity:

TBD

In vivo activity:

LY334370 significantly inhibited activation of second-order neurons in the trigeminal nucleus caudalis produced by electrical stimulation of the dura mater in anesthetised rats at 3 mg kg-1, i.v. These results provide evidence to suggest that LY334370 has a central mechanism of action in blocking the transmission of nociceptive impulses within the trigeminal nucleus caudalis and that this may represent a mechanism through which it has its antimigraine effect. Reference: Cephalalgia. 1999 Dec;19(10):851-8. https://pubmed.ncbi.nlm.nih.gov/10668103/

Preparing Stock Solutions

The following data is based on the product molecular weight 387.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Filla SA, Mathes BM, Johnson KW, Phebus LA, Cohen ML, Nelson DL, Zgombick JM, Erickson JA, Schenck KW, Wainscott DB, Branchek TA, Schaus JM. Novel potent 5-HT(1F) receptor agonists: structure-activity studies of a series of substituted N-[3-(1-methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides. J Med Chem. 2003 Jul 3;46(14):3060-71. doi: 10.1021/jm030020m. PMID: 12825944. 2. Shepheard S, Edvinsson L, Cumberbatch M, Williamson D, Mason G, Webb J, Boyce S, Hill R, Hargreaves R. Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY334370. Cephalalgia. 1999 Dec;19(10):851-8. doi: 10.1046/j.1468-2982.1999.1910851.x. PMID: 10668103.

In vitro protocol:

TBD

In vivo protocol:

1: Goldstein DJ, Roon KI, Offen WW, Ramadan NM, Phebus LA, Johnson KW, Schaus JM, Ferrari MD. Selective seratonin 1F (5-HT(1F)) receptor agonist LY334370 for acute migraine: a randomised controlled trial. Lancet. 2001 Oct 13;358(9289):1230-4. PubMed PMID: 11675061. 2: Shepheard S, Edvinsson L, Cumberbatch M, Williamson D, Mason G, Webb J, Boyce S, Hill R, Hargreaves R. Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY334370. Cephalalgia. 1999 Dec;19(10):851-8. PubMed PMID: 10668103.