MedKoo Cat#: 532156 | Name: LY307452

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LY307452 is a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3).

Chemical Structure

LY307452
LY307452
CAS#174393-13-6

Theoretical Analysis

MedKoo Cat#: 532156

Name: LY307452

CAS#: 174393-13-6

Chemical Formula: C21H25NO4

Exact Mass: 355.1784

Molecular Weight: 355.43

Elemental Analysis: C, 70.96; H, 7.09; N, 3.94; O, 18.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LY307452; LY 307452; LY-307452.
IUPAC/Chemical Name
(2S,4S)-2-amino-4-(4,4-diphenylbutyl)pentanedioic acid
InChi Key
DWLOVDOPFJPWNE-HKUYNNGSSA-N
InChi Code
InChI=1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1
SMILES Code
O=C(O)[C@@H](N)C[C@H](CCCC(C1=CC=CC=C1)C2=CC=CC=C2)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 355.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sung KW, Choi S, Lovinger DM. Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses. J Neurophysiol. 2001 Nov;86(5):2405-12. PubMed PMID: 11698530. 2: Li XC, Beart PM, Monn JA, Jones NM, Widdop RE. Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats. Br J Pharmacol. 1999 Oct;128(3):823-9. PubMed PMID: 10516668; PubMed Central PMCID: PMC1571690. 3: Dutar P, Vu HM, Perkel DJ. Pharmacological characterization of an unusual mGluR-evoked neuronal hyperpolarization mediated by activation of GIRK channels. Neuropharmacology. 1999 Apr;38(4):467-75. PubMed PMID: 10221750. 4: Jones NM, Monn JA, Beart PM. Type I and II metabotropic glutamate receptors regulate the outflow of [3H]D-aspartate and [14C]gamma-aminobutyric acid in rat solitary nucleus. Eur J Pharmacol. 1998 Jul 17;353(1):43-51. PubMed PMID: 9721038. 5: Salt TE, Turner JP. Modulation of sensory inhibition in the ventrobasal thalamus via activation of group II metabotropic glutamate receptors by 2R,4R-aminopyrrolidine-2,4-dicarboxylate. Exp Brain Res. 1998 Jul;121(2):181-5. PubMed PMID: 9696387. 6: Mistry R, Golding N, Challiss RA. Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists. Br J Pharmacol. 1998 Feb;123(3):581-9. PubMed PMID: 9504400; PubMed Central PMCID: PMC1565187. 7: Schoepp DD, Johnson BG, Wright RA, Salhoff CR, Mayne NG, Wu S, Cockerman SL, Burnett JP, Belegaje R, Bleakman D, Monn JA. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Neuropharmacology. 1997 Jan;36(1):1-11. PubMed PMID: 9144636.