LP-44 hydrochloride is a high affinity 5-HT7 receptor agonist (Ki = 0.22 nM) that displays selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). LP-44 dnduces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
MedKoo Cat#: 532117
Name: LP-44 hydrochloride
CAS#: 824958-12-5 (HCl)
Chemical Formula: C27H38ClN3OS
Exact Mass: 0.0000
Molecular Weight: 488.13
Elemental Analysis: C, 66.44; H, 7.85; Cl, 7.26; N, 8.61; O, 3.28; S, 6.57
Solvent | mg/mL | mM | |
---|---|---|---|
Solubility | |||
DMF | 10.0 | 20.49 | |
DMSO | 10.0 | 20.49 | |
DMSO:PBS (pH 7.2) (1:2) | 0.3 | 0.51 | |
Ethanol | 10.0 | 20.49 |
The following data is based on the product molecular weight 488.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |