HM-50316 | HM 50316 | CAS#1310361-52-4

MedKoo Cat#: 530530 | Name: HM-50316

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HM-50316 is a High affinity FABP4 inhibitor (Ki < 1 nM). HM-50316 may serve as a lead compound for developing new effective therapeutic agent for prevention and treatment of atherosclerosis, type 2 diabetes and other inflammatory and metabolic related diseases. a-FABP is indespensible in inflammation and may serve as a new potential drug target for inflammation related diseases.

Chemical Structure

HM-50316

CAS#1310361-52-4

Theoretical Analysis

MedKoo Cat#: 530530

Name: HM-50316

CAS#: 1310361-52-4

Chemical Formula: C29H23ClN2O3S

Exact Mass: 514.1118

Molecular Weight: 515.02

Elemental Analysis: C, 67.63; H, 4.50; Cl, 6.88; N, 5.44; O, 9.32; S, 6.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

HM-50316; HM 50316; HM50316.

IUPAC/Chemical Name

2-[[2'-[1-(4-Chlorophenyl)-5-(2-thienyl)-1H-pyrazol-3-yl][1,1'-biphenyl]-3-yl]oxy]-2-methylpropanoic acid

InChi Key

HOACFVYJBHHSBC-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H23ClN2O3S/c1-29(2,28(33)34)35-22-8-5-7-19(17-22)23-9-3-4-10-24(23)25-18-26(27-11-6-16-36-27)32(31-25)21-14-12-20(30)13-15-21/h3-18H,1-2H3,(H,33,34)

SMILES Code

CC(C)(OC1=CC(C2=CC=CC=C2C3=NN(C4=CC=C(Cl)C=C4)C(C5=CC=CS5)=C3)=CC=C1)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 515.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liu X, Huang X, Lin W, Wang D, Diao Y, Li H, Hui X, Wang Y, Xu A, Wu D, Ke D. New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg Med Chem Lett. 2011 May 15;21(10):2949-52. doi: 10.1016/j.bmcl.2011.03.063. PubMed PMID: 21481589.