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MedKoo Cat#: 530529 | Name: SHIP-2a

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SHIP-2a is a cystathione γ lyase (CSE) inhibitor (IC50 = 6.3 μM)

Chemical Structure

SHIP-2a
SHIP-2a
CAS#1250186-20-9 (racemic)

Theoretical Analysis

MedKoo Cat#: 530529

Name: SHIP-2a

CAS#: 1250186-20-9 (racemic)

Chemical Formula: C7H8N2O2S

Exact Mass: 184.0306

Molecular Weight: 184.21

Elemental Analysis: C, 45.64; H, 4.38; N, 15.21; O, 17.37; S, 17.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SHIP-2a; SHIP 2a; SHIP2a.
IUPAC/Chemical Name
(R)-2-Oxo-N-2-propyn-1-yl-4-thiazolidinecarboxamide
InChi Key
MWEQVHWJNCRXGP-YFKPBYRVSA-N
InChi Code
InChI=1S/C7H8N2O2S/c1-2-3-8-6(10)5-4-12-7(11)9-5/h1,5H,3-4H2,(H,8,10)(H,9,11)/t5-/m0/s1
SMILES Code
O=C([C@H]1NC(SC1)=O)NCC#C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Hydrogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases from hypertension to stroke, diabetes and pancreatitis. It is endogenously synthesized mainly by two pyridoxal-5'-phosphate-dependent enzymes involved in L-cysteine metabolism: cystathionine-ß-synthase (CBS) and cystathionine-γ-lyase (CSE).

Preparing Stock Solutions

The following data is based on the product molecular weight 184.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Corvino A, Severino B, Fiorino F, Frecentese F, Magli E, Perissutti E, Santagada V, Bucci M, Cirino G, Kelly G, Servillo L, Popowicz G, Pastore A, Caliendo G. Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci Rep. 2016 Oct 6;6:34398. doi: 10.1038/srep34398. PubMed PMID: 27708394; PubMed Central PMCID: PMC5052628.