L-750,667 TriHydrochloride | CAS#1021868-80-3 | D4 Receptor Antagonist

MedKoo Cat#: 532083 | Name: L-750,667 TriHydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-750,667 TriHydrochloride is a selective D4 dopamine receptor antagonist.

Chemical Structure

L-750,667 TriHydrochloride

CAS#1021868-80-3

Theoretical Analysis

MedKoo Cat#: 532083

Name: L-750,667 TriHydrochloride

CAS#: 1021868-80-3

Chemical Formula: C18H22Cl3IN4

Exact Mass:

Molecular Weight: 527.66

Elemental Analysis: C, 40.97; H, 4.20; Cl, 20.16; I, 24.05; N, 10.62

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 585.00	2 Weeks

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Related CAS #

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Synonym

L-750,667; L 750,667; L750,667.

IUPAC/Chemical Name

3-[4-(4-Iodophenyl)piperazin-1-yl]methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride

InChi Key

YOURSPNOEWYAKO-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H19IN4.3ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;;;/h1-7,12H,8-11,13H2,(H,20,21);3*1H

SMILES Code

IC1=CC=C(N2CCN(CC3=CNC4=NC=CC=C43)CC2)C=C1.[H]Cl.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

L-750,667 TriHydrochloride is a selective D4 dopamine receptor antagonist.

In vitro activity:

In contrast to RBI-257 which is an antagonist at all receptors, L-750,667 is a partial agonist at the wild-type D(2) but an antagonist at both the mutant D(2) and wild-type D(4) receptors. Reference: J Neurochem. 2009 Jul;110(1):45-57. https://pubmed.ncbi.nlm.nih.gov/19486266/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 527.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Cummings DF, Ericksen SS, Schetz JA. Three amino acids in the D2 dopamine receptor regulate selective ligand function and affinity. J Neurochem. 2009 Jul;110(1):45-57. doi: 10.1111/j.1471-4159.2009.06103.x. Epub 2009 Apr 16. PMID: 19486266; PMCID: PMC4896224. 2. Nakano K, Higashi T, Hashimoto K, Takagi R, Tanaka Y, Matsushita S. Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis. Biochem Biophys Res Commun. 2008 Aug 22;373(2):286-91. doi: 10.1016/j.bbrc.2008.06.012. Epub 2008 Jun 17. PMID: 18558081.

In vitro protocol:

In vivo protocol:

TBD

1: Kawano M, Takagi R, Kaneko A, Matsushita S. Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses. J Neuroimmunol. 2015 Dec 15;289:43-55. doi: 10.1016/j.jneuroim.2015.10.001. PubMed PMID: 26616870.