Synonym
Org-21465; Org 21465; Org21465
IUPAC/Chemical Name
(2S,3S,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-2-(2,2-dimethylmorpholino)-3-hydroxy-10,13-dimethylhexadecahydro-11H-cyclopenta[a]phenanthren-11-one
InChi Key
HQEJMKVZYCQIIH-JJLPOIBOSA-N
InChi Code
InChI=1S/C27H43NO4/c1-16(29)19-8-9-20-18-7-6-17-12-22(30)21(28-10-11-32-25(2,3)15-28)13-26(17,4)24(18)23(31)14-27(19,20)5/h17-22,24,30H,6-15H2,1-5H3/t17-,18-,19+,20-,21-,22-,24+,26-,27+/m0/s1
SMILES Code
CC1(C)OCCN([C@@H]2[C@@H](O)C[C@@](CC[C@]([C@@](CC[C@@H]3C(C)=O)([H])[C@]3(C)C4)([H])[C@]5([H])C4=O)([H])[C@]5(C)C2)C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
445.64
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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4: Sneyd JR, Wright PM, Harris D, Taylor PA, Vijn PC, Cross M, Dale H, Voortman G, Boen P. Computer-controlled infusion of ORG 21465, a water soluble steroid i.v. anaesthetic agent, into human volunteers. Br J Anaesth. 1997 Oct;79(4):433-9. Erratum in: Br J Anaesth 2001 Feb;86(2):302. PubMed PMID: 9389258.
5: Sneyd JR, Wright PM, Cross M, Thompson P, Voortman G, Weideman MM, Andrews CJ, Daniell CJ. Administration to humans of ORG 21465, a water soluble steroid i.v. anaesthetic agent. Br J Anaesth. 1997 Oct;79(4):427-32. PubMed PMID: 9389257.
6: Sear JW. ORG 21465, a new water-soluble steroid hypnotic: more of the same or something different? Br J Anaesth. 1997 Oct;79(4):417-9. PubMed PMID: 9389254.
