KUL-7211 is an β2 and β3 adrenergic receptor agonist potentially for the treatment of pain and urinary tract stones. KUL-7211 is a potent ureteral relaxant with a relatively small hypotensive effect. KUL-7211 relaxed 80-mM-KCl-induced tonic contractions in both rabbit (pD(2) value: 5.86 +/- 0.13, whose ureteral relaxation is mediated via beta(2)-adrenergic stimulation) and canine (pD(2) value: 6.52 +/- 0.16, via beta(3)-adrenergic stimulation) isolated ureters in a concentration-dependent manner. KUL-7211 also reduced the spontaneous rhythmic contraction in a canine ureteral spiral preparation in a concentration-dependent manner, the pD(2) value being 6.83 +/- 0.20.
MedKoo Cat#: 528322
Name: KUL-7211
CAS#: 220129-58-8
Chemical Formula: C19H23NO5
Exact Mass: 345.1576
Molecular Weight: 345.40
Elemental Analysis: C, 66.07; H, 6.71; N, 4.06; O, 23.16
The following data is based on the product molecular weight 345.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
