MedKoo Cat#: 407407 | Name: Compound 401
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Compound 401 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively).

Chemical Structure

Compound 401
CAS#168425-64-7

Theoretical Analysis

MedKoo Cat#: 407407

Name: Compound 401

CAS#: 168425-64-7

Chemical Formula: C16H15N3O2

Exact Mass: 281.1164

Molecular Weight: 281.32

Elemental Analysis: C, 68.31; H, 5.37; N, 14.94; O, 11.37

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Compound 401; Compound-401; Compound401.
IUPAC/Chemical Name
2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
InChi Key
BVRDQVRQVGRNHG-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2
SMILES Code
O=C1C=C(N2CCOCC2)N=C3N1C=CC4=C3C=CC=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 281.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ballou LM, Selinger ES, Choi JY, Drueckhammer DG, Lin RZ. Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282(33):24463-70. PubMed PMID: 17562705.