Synonym
V-0162; V0162; V 0162; (R)-Mequitazine;
IUPAC/Chemical Name
(R)-10-(quinuclidin-3-ylmethyl)-10H-phenothiazine
InChi Key
HOKDBMAJZXIPGC-MRXNPFEDSA-N
InChi Code
InChI=1S/C20H22N2S/c1-3-7-19-17(5-1)22(18-6-2-4-8-20(18)23-19)14-16-13-21-11-9-15(16)10-12-21/h1-8,15-16H,9-14H2/t16-/m1/s1
SMILES Code
C12=CC=CC=C1N(C[C@H]3CN4CCC3CC4)C5=C(C=CC=C5)S2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
322.47
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Fonlupt P, Dubois M, Gallet H, Biot N, Pacheco H. [Changes in leukocyte phospholipid-N-methyltransferase activity after chronic treatment of allergic patients with mequitazine]. C R Seances Acad Sci III. 1983;296(21):1005-7. French. PubMed PMID: 6413002.
2: De Rotalier P, Faye M, Sissokho B, Fall D. [Allergies in ENT]. Dakar Med. 2007;52(1):2-6. French. PubMed PMID: 19102083.
3: ter Laak AM, Venhorst J, Donné-Op den Kelder GM, Timmerman H. The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor. J Med Chem. 1995 Aug 18;38(17):3351-60. PubMed PMID: 7650688.
4: Di Bugno C, Dapporto P, Giorgi R, Manzini S, Paoli P, Subissi A, Arcamone F. Absolute configuration and biological activity of mequitamium iodide enantiomers. Chirality. 1994;6(5):382-8. PubMed PMID: 8068497.
5: D'Souza MF, Tooley M, Charlton JR. Hay fever treatments--which should be tried first? J R Coll Gen Pract. 1987 Jul;37(300):296-300. PubMed PMID: 2896796; PubMed Central PMCID: PMC1710933.
