UK 357903 | CAS#247580-98-9 | PDE5A Inhibitor

MedKoo Cat#: 529215 | Name: UK 357903

Description:

WARNING: This product is for research use only, not for human or veterinary use.

UK 357903 is a phosphodiesterase 5A (PDE5A) inhibitor potentially for the treatment of erectile dysfunction.

Chemical Structure

UK 357903

CAS#247580-98-9

Theoretical Analysis

MedKoo Cat#: 529215

Name: UK 357903

CAS#: 247580-98-9

Chemical Formula: C27H34N8O5S

Exact Mass: 582.2373

Molecular Weight: 582.68

Elemental Analysis: C, 55.66; H, 5.88; N, 19.23; O, 13.73; S, 5.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

UK-357903, UK357903, UK 357903

IUPAC/Chemical Name

3-ethyl-5-(5-((4-ethylpiperazin-1-yl)sulfonyl)-2-(2-methoxyethoxy)pyridin-3-yl)-2-(pyridin-2-ylmethyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

InChi Key

QDPNAMRLQRQPMR-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H34N8O5S/c1-4-22-23-24(32-35(22)18-19-8-6-7-9-28-19)26(36)31-25(30-23)21-16-20(17-29-27(21)40-15-14-39-3)41(37,38)34-12-10-33(5-2)11-13-34/h6-9,16-17H,4-5,10-15,18H2,1-3H3,(H,30,31,36)

SMILES Code

O=C1C2=NN(CC3=NC=CC=C3)C(CC)=C2N=C(C4=CC(S(=O)(N5CCN(CC)CC5)=O)=CN=C4OCCOC)N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 582.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gardiner SM, March JE, Kemp PA, Ballard SA, Hawkeswood E, Hughes B, Bennett T. Haemodynamic effects of the selective phosphodiesterase 5 inhibitor, UK-357,903, in conscious SHR. Br J Pharmacol. 2004 Jan;141(1):114-22. PubMed PMID: 14662738; PubMed Central PMCID: PMC1574167. 2: Gardiner SM, March JE, Kemp PA, Ballard SA, Hawkeswood E, Hughes B, Bennett T. Hemodynamic effects of phosphodiesterase 5 and angiotensin-converting enzyme inhibition alone or in combination in conscious SHR. J Pharmacol Exp Ther. 2005 Jan;312(1):265-71. PubMed PMID: 15452190.