MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 529211 | Name: R-932348 choline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

R-932348 choline is a dual JAK/SYK inhibitor potentially for treatment of dry eye disease.

Chemical Structure

R-932348 choline
R-932348 choline
CAS#1620142-65-5 (choline salt)

Theoretical Analysis

MedKoo Cat#: 529211

Name: R-932348 choline

CAS#: 1620142-65-5 (choline salt)

Chemical Formula: C28H36FN6O5S+

Exact Mass:

Molecular Weight: 587.69

Elemental Analysis: C, 57.23; H, 6.17; F, 3.23; N, 14.30; O, 13.61; S, 5.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
916742-11-5 (R-932348 free base)
Synonym
R-932348; R-348; R932348; R348; R 932348; R 348
IUPAC/Chemical Name
(Z)-N-((5-((5-fluoro-4-((4-(prop-2-yn-1-yloxy)phenyl)amino)pyrimidin-2-yl)amino)-2-methylphenyl)sulfonyl)propionimidic acid, 2-hydroxy-N,N,N-trimethylethan-1-aminium salt
InChi Key
LVRVZPFTLOJOOC-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H22FN5O4S.C5H14NO/c1-4-12-33-18-10-8-16(9-11-18)26-22-19(24)14-25-23(28-22)27-17-7-6-15(3)20(13-17)34(31,32)29-21(30)5-2;1-6(2,3)4-5-7/h1,6-11,13-14H,5,12H2,2-3H3,(H,29,30)(H2,25,26,27,28);7H,4-5H2,1-3H3/q;+1
SMILES Code
C[N+](C)(CCO)C.CC/C(O)=N/S(=O)(C1=CC(NC2=NC=C(F)C(NC3=CC=C(OCC#C)C=C3)=N2)=CC=C1C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 587.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Velotta JB, Deuse T, Haddad M, Masuda E, Park G, Carroll D, Taylor V, Robbins RC, Schrepfer S. A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection. Transplantation. 2009 Mar 15;87(5):653-9. doi: 10.1097/TP.0b013e318196110f. PubMed PMID: 19295308. 2: Deuse T, Velotta JB, Hoyt G, Govaert JA, Taylor V, Masuda E, Herlaar E, Park G, Carroll D, Pelletier MP, Robbins RC, Schrepfer S. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection. Transplantation. 2008 Mar 27;85(6):885-92. doi: 10.1097/TP.0b013e318166acc4. PubMed PMID: 18360272. 3: Cheung LW, Yu S, Zhang D, Li J, Ng PK, Panupinthu N, Mitra S, Ju Z, Yu Q, Liang H, Hawke DH, Lu Y, Broaddus RR, Mills GB. Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors. Cancer Cell. 2014 Oct 13;26(4):479-94. doi: 10.1016/j.ccell.2014.08.017. PubMed PMID: 25284480; PubMed Central PMCID: PMC4198486. 4: Chang BY, Zhao F, He X, Ren H, Braselmann S, Taylor V, Wicks J, Payan DG, Grossbard EB, Pine PR, Bullard DC. JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice. J Immunol. 2009 Aug 1;183(3):2183-92. doi: 10.4049/jimmunol.0804063. PubMed PMID: 19596999. 5: Xie W, Burke B. Lamins. Curr Biol. 2016 May 9;26(9):R348-50. doi: 10.1016/j.cub.2016.01.055. PubMed PMID: 27166687. 6: Wolfe J. Jeremy Wolfe. Curr Biol. 2015 May 4;25(9):R348-9. PubMed PMID: 26146677. 7: Silliman BR. Salt marshes. Curr Biol. 2014 May 5;24(9):R348-50. doi: 10.1016/j.cub.2014.03.001. PubMed PMID: 24801180. 8: Piña-Aguilar RE, Vera-Loaiza A, Chacón-Camacho OF, Zenteno JC, Nuñez-Orozco L, Santillán-Hernández Y. Clinical and genetic characteristics of mexican patients with juvenile presentation of niemann-pick type C disease. Case Rep Neurol Med. 2014;2014:785890. doi: 10.1155/2014/785890. PubMed PMID: 25349751; PubMed Central PMCID: PMC4202276. 9: Kwatra SG, Dabade TS, Gustafson CJ, Feldman SR. JAK inhibitors in psoriasis: a promising new treatment modality. J Drugs Dermatol. 2012 Aug;11(8):913-8. Review. PubMed PMID: 22859235. 10: Osman AA, Babu PR, Venu K, Rao KV, Reddy VD. Prediction of substrate-binding site and elucidation of catalytic residue of a phytase from Bacillus sp. Enzyme Microb Technol. 2012 Jun 10;51(1):35-9. doi: 10.1016/j.enzmictec.2012.03.010. PubMed PMID: 22579388. 11: Land M. Biological optics: circularly polarised crustaceans. Curr Biol. 2008 Apr 22;18(8):R348-9. doi: 10.1016/j.cub.2008.02.030. PubMed PMID: 18430637. 12: Ptashne M. On speaking, writing and inspiration. Curr Biol. 2007 May 15;17(10):R348-9. PubMed PMID: 17502082. 13: Steiner AA, Chakravarty S, Robbins JR, Dragic AS, Pan J, Herkenham M, Romanovsky AA. Thermoregulatory responses of rats to conventional preparations of lipopolysaccharide are caused by lipopolysaccharide per se-- not by lipoprotein contaminants. Am J Physiol Regul Integr Comp Physiol. 2005 Aug;289(2):R348-R352. PubMed PMID: 15860647. 14: Doran SA, Tran CH, Eskicioglu C, Stachniak T, Ahn KC, Goldberg JI. Constitutive and permissive roles of nitric oxide activity in embryonic ciliary cells. Am J Physiol Regul Integr Comp Physiol. 2003 Aug;285(2):R348-55. PubMed PMID: 12676758. 15: Eeckhoute J, Oxombre B, Formstecher P, Lefebvre P, Laine B. Critical role of charged residues in helix 7 of the ligand binding domain in Hepatocyte Nuclear Factor 4alpha dimerisation and transcriptional activity. Nucleic Acids Res. 2003 Nov 15;31(22):6640-50. PubMed PMID: 14602925; PubMed Central PMCID: PMC275546. 16: Thompson I. Cortical development: Binocular plasticity turned outside-in. Curr Biol. 2000 May 4;10(9):R348-50. Review. PubMed PMID: 10801431. 17: Kazmierczak RA, Swalla BM, Burgin AB, Gumport RI, Gardner JF. Regulation of site-specific recombination by the C-terminus of lambda integrase. Nucleic Acids Res. 2002 Dec 1;30(23):5193-204. PubMed PMID: 12466544; PubMed Central PMCID: PMC137966. 18: Takagi S, Kihara Y, Sasayama S, Mitsuiye T. Slow inactivation of cardiac L-type Ca2+ channel induced by cold acclimation of guinea pig. Am J Physiol. 1998 Feb;274(2 Pt 2):R348-56. PubMed PMID: 9486291. 19: Maj MC, Singh B, Gupta RS. Structure-activity studies on mammalian adenosine kinase. Biochem Biophys Res Commun. 2000 Aug 28;275(2):386-93. PubMed PMID: 10964675. 20: Carpenter RH. Sensorimotor processing: charting the frontier. Curr Biol. 1997 Jun 1;7(6):R348-51. Review. PubMed PMID: 9197226.

View History

Rosaramicin butyrate

Rosaramicin butyrate