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MedKoo Cat#: 407400 | Name: CBB1007

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CBB1007 is a potent and selective Lysine-specific demethylase 1 (LSD1) inhibitor. CBB1007 protect cochlear spiral ganglion neurons against cisplatin-induced damage. CBB1007 promotes the adipogenic differentiation of hESCs. Inhibition of H3K4me2 Demethylation Protects Auditory Hair Cells from Neomycin-Induced Apoptosis.

Chemical Structure

CBB1007
CBB1007
CAS#1379573-92-8

Theoretical Analysis

MedKoo Cat#: 407400

Name: CBB1007

CAS#: 1379573-92-8

Chemical Formula:

Exact Mass:

Molecular Weight:

Elemental Analysis:

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CBB1007; CBB-1007; CBB 1007.
IUPAC/Chemical Name
methyl 3-(4-(4-carbamimidoylbenzoyl)piperazine-1-carbonyl)-5-((4-carbamimidoylpiperazin-1-yl)methyl)benzoate
InChi Key
IBVRETRIDAQSEM-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H34N8O4/c1-39-26(38)22-15-18(17-32-6-8-35(9-7-32)27(30)31)14-21(16-22)25(37)34-12-10-33(11-13-34)24(36)20-4-2-19(3-5-20)23(28)29/h2-5,14-16H,6-13,17H2,1H3,(H3,28,29)(H3,30,31)
SMILES Code
O=C(OC)C1=CC(CN2CCN(C(N)=N)CC2)=CC(C(N3CCN(C(C4=CC=C(C(N)=N)C=C4)=O)CC3)=O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Singh AK, Chandra N, Bapat SA. Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer. Clin Cancer Res. 2015 Nov 15;21(22):5151-63. doi: 10.1158/1078-0432.CCR-15-0505. PubMed PMID: 26130461. 2: Li A, He Y, Sun S, Cai C, Li H. Lysine-specific demethylase 1 inhibitors protect cochlear spiral ganglion neurons against cisplatin-induced damage. Neuroreport. 2015 Jun 17;26(9):539-47. doi: 10.1097/WNR.0000000000000386. PubMed PMID: 26011390. 3: Xiong Y, Wang E, Huang Y, Guo X, Yu Y, Du Q, Ding X, Sun Y. Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation. Stem Cell Rev. 2016 Jun;12(3):298-304. doi: 10.1007/s12015-016-9650-z. PubMed PMID: 27059868; PubMed Central PMCID: PMC4879152. 4: He Y, Yu H, Cai C, Sun S, Chai R, Li H. Inhibition of H3K4me2 Demethylation Protects Auditory Hair Cells from Neomycin-Induced Apoptosis. Mol Neurobiol. 2015 Aug;52(1):196-205. doi: 10.1007/s12035-014-8841-3. PubMed PMID: 25132091. 5: Konovalov S, Garcia-Bassets I. Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines. J Ovarian Res. 2013 Oct 29;6(1):75. doi: 10.1186/1757-2215-6-75. PubMed PMID: 24165091; PubMed Central PMCID: PMC4176291.