Idremcinal | CAS#110480-13-2 | motilin receptor agonist

MedKoo Cat#: 529209 | Name: Idremcinal

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Idremcinal is a motilin receptor agonist potentially for the treatment of gastritis

Chemical Structure

Idremcinal

CAS#110480-13-2

Theoretical Analysis

MedKoo Cat#: 529209

Name: Idremcinal

CAS#: 110480-13-2

Chemical Formula: C39H69NO12

Exact Mass: 743.4820

Molecular Weight: 743.97

Elemental Analysis: C, 62.96; H, 9.35; N, 1.88; O, 25.81

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 550.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

EM-574; EM574; EM 574;

IUPAC/Chemical Name

(2R,3R,4S,5R,8R,9S,10S,11R,12R)-5-ethyl-3,4-dihydroxy-11-(((2S,3R,4S,6R)-3-hydroxy-4-(isopropyl(methyl)amino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-9-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-2,4,8,10,12,14-hexamethyl-6,15-dioxabicyclo[10.2.1]pentadec-1(14)-en-7-one

InChi Key

FPBKIOZMKHHNLL-CBUZSSJJSA-N

InChi Code

InChI=1S/C39H69NO12/c1-15-27-39(12,45)32(42)22(6)30-20(4)17-38(11,52-30)34(51-36-29(41)26(16-21(5)47-36)40(13)19(2)3)23(7)31(24(8)35(44)49-27)50-28-18-37(10,46-14)33(43)25(9)48-28/h19,21-29,31-34,36,41-43,45H,15-18H2,1-14H3/t21-,22+,23+,24-,25+,26+,27-,28+,29-,31+,32-,33+,34-,36+,37-,38-,39-/m1/s1

SMILES Code

O=C1O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(O2)=C(C)C[C@]2(C)[C@H](O[C@@H]3O[C@H](C)C[C@H](N(C)C(C)C)[C@H]3O)[C@@H](C)[C@H](O[C@@H]4O[C@@H](C)[C@H](O)[C@](C)(OC)C4)[C@H]1C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 743.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Yogo K, Onoma M, Ozaki K, Koto M, Itoh Z, Omura S, Takanashi H. Effects of oral mitemcinal (GM-611), erythromycin, EM-574 and cisapride on gastric emptying in conscious rhesus monkeys. Dig Dis Sci. 2008 Apr;53(4):912-8. PubMed PMID: 17934842. 2: Ozaki K, Yogo K, Sudo H, Onoma M, Kamei K, Akima M, Koga H, Itoh Z, Omura S, Takanashi H. Effects of mitemcinal (GM-611), an acid-resistant nonpeptide motilin receptor agonist, on the gastrointestinal contractile activity in conscious dogs. Pharmacology. 2007;79(4):223-35. PubMed PMID: 17426410. 3: Takanashi H, Yogo K, Ozaki K, Koga H, Itoh Z, Omura S. In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine. Pharmacology. 2007;79(3):137-48. PubMed PMID: 17183187. 4: Asakawa A, Akio I, Ohinata K, Fujimiya M, Meguid MM, Yoshikawa M. EM574, a motilide, has an orexigenic activity with affinity for growth-hormone secretagogue receptor. J Gastroenterol Hepatol. 2003 Jul;18(7):881-2. PubMed PMID: 12795766. 5: Asakawa A, Inui A, Ueno N, Makino S, Uemoto M, Fujino MA, Kasuga M. Ob/ob mice as a model of delayed gastric emptying. J Diabetes Complications. 2003 Jan-Feb;17(1):27-8. PubMed PMID: 12505753. 6: Gan G, Cartier LL, Huang Y, Yang Z, Sawchuk RJ. Intestinal absorption and presystemic elimination of the prokinetic agent, EM574, in the rabbit. J Pharm Sci. 2002 Jan;91(1):217-28. PubMed PMID: 11782911. 7: Sato F, Marui S, Inatomi N, Itoh Z, Omura S. EM574, an erythromycin derivative, improves delayed gastric emptying of semi-solid meals in conscious dogs. Eur J Pharmacol. 2000 Apr 28;395(2):165-72. Erratum in: Eur J Pharmacol 2000 Sep 22;404(3):397. PubMed PMID: 10794824. 8: Kondo T, Dote N, Hagimoto T, Yoshimura Y. Application of liquid chromatography-turbo ion spray tandem mass spectrometry for quantitative analysis of a potent motilin receptor agonist, EM574, and its metabolites in human plasma. J Chromatogr B Biomed Sci Appl. 1999 Oct 29;734(1):101-12. PubMed PMID: 10574195. 9: Tanaka T, Mizumoto A, Mochiki E, Suzuki H, Itoh Z, Omura S. Effect of EM574 on postprandial pancreaticobiliary secretion, gastric motor activity, and emptying in conscious dogs. Dig Dis Sci. 1999 Jun;44(6):1100-6. PubMed PMID: 10389679. 10: Tanaka T, Mizumoto A, Mochiki E, Suzuki H, Itoh Z, Omura S. Effects of EM574 and cisapride on gastric contractile and emptying activity in normal and drug-induced gastroparesis in dogs. J Pharmacol Exp Ther. 1998 Nov;287(2):712-9. PubMed PMID: 9808701. 11: Choi MG, Camilleri M, Burton DD, Johnson S, Edmonds A. Dose-related effects of N-demethyl-N-isopropyl-8, 9-anhydroerythromycin A 6,9-hemiacetal on gastric emptying of solids in healthy human volunteers. J Pharmacol Exp Ther. 1998 Apr;285(1):37-40. PubMed PMID: 9535992. 12: Sato F, Sekiguchi M, Marui S, Inatomi N, Shino A, Itoh Z, Omura S. EM574, an erythromycin derivative, is a motilin receptor agonist in the rabbit. Eur J Pharmacol. 1997 Mar 12;322(1):63-71. PubMed PMID: 9088872. 13: Funabashi Y, Maeshiba Y, Inatomi N, Tanayama S, Harada S, Itoh Z, Omura S. Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activity. J Antibiot (Tokyo). 1996 Aug;49(8):794-801. PubMed PMID: 8823513. 14: Itoh Z. Motilin and clinical application. Peptides. 1997;18(4):593-608. Review. PubMed PMID: 9210180. 15: Inatomi N, Sato F, Marui S, Itoh Z, Omura S. Vagus-dependent and vagus-independent mechanisms of action of the erythromycin derivative EM574 and motilin in dogs. Jpn J Pharmacol. 1996 May;71(1):29-38. PubMed PMID: 8791169. 16: Funabashi Y, Hakoda S, Inatomi N, Koyama K, Tanida S, Harada S, Itoh Z, Omura S. Microbial conversion of EM574 and EM523, gastrointestinal motor stimulating agents. J Antibiot (Tokyo). 1996 Aug;49(8):802-10. PubMed PMID: 8823514. 17: Sato M, Sakai T, Sano I, Ito S. [Erythromycin derivative EM574 with motilin agonistic effect on human gastric antrum]. J Smooth Muscle Res. 1995 Dec;31(6):495-8. Japanese. PubMed PMID: 8867985. 18: Satoh M, Sakai T, Sano I, Fujikura K, Koyama H, Ohshima K, Itoh Z, Omura S. EM574, an erythromycin derivative, is a potent motilin receptor agonist in human gastric antrum. J Pharmacol Exp Ther. 1994 Oct;271(1):574-9. PubMed PMID: 7965757.