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MedKoo Cat#: 529202 | Name: CMX-2043

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CMX-2043 is a drug potentially to activate cell survival pathways and block oxidative damage.

Chemical Structure

CMX-2043
CMX-2043
CAS#910627-26-8

Theoretical Analysis

MedKoo Cat#: 529202

Name: CMX-2043

CAS#: 910627-26-8

Chemical Formula: C16H26N2O6S2

Exact Mass: 406.1232

Molecular Weight: 406.51

Elemental Analysis: C, 47.27; H, 6.45; N, 6.89; O, 23.61; S, 15.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CMX-2043; CMX2043; CMX2043; LIP-EA; R-LIP-EA-OH; LIPEA; RLIPEAOH; LIP EA; R LIP EA OH
IUPAC/Chemical Name
(S)-4-(5-((R)-1,2-dithiolan-3-yl)pentanamido)-5-(((S)-1-carboxyethyl)amino)-5-oxopentanoic acid
InChi Key
MQXRTCVZPIHBLD-TUAOUCFPSA-N
InChi Code
InChI=1S/C16H26N2O6S2/c1-10(16(23)24)17-15(22)12(6-7-14(20)21)18-13(19)5-3-2-4-11-8-9-25-26-11/h10-12H,2-9H2,1H3,(H,17,22)(H,18,19)(H,20,21)(H,23,24)/t10-,11+,12-/m0/s1
SMILES Code
C[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC(CCCC[C@H]1SSCC1)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 406.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lader AS, Baguisi A, Casale R, Kates SA, Beeuwkes R 3rd. CMX-2043 Mechanisms of Action In Vitro. J Cardiovasc Pharmacol. 2016 Sep;68(3):241-7. doi: 10.1097/FJC.0000000000000408. PubMed PMID: 27195653. 2: Baguisi A, Casale RA, Kates SA, Lader AS, Stewart K, Beeuwkes R 3rd. CMX-2043 Efficacy in a Rat Model of Cardiac Ischemia-Reperfusion Injury. J Cardiovasc Pharmacol Ther. 2016 Nov;21(6):563-569. PubMed PMID: 27113210. 3: Kates SA, Lader AS, Casale R, Beeuwkes R 3rd. Pre-clinical and Clinical Safety Studies of CMX-2043: a cytoprotective lipoic acid analogue for ischaemia-reperfusion injury. Basic Clin Pharmacol Toxicol. 2014 Nov;115(5):456-64. doi: 10.1111/bcpt.12254. PubMed PMID: 24751172; PubMed Central PMCID: PMC4270215. 4: Kates SA, Casale RA, Baguisi A, Beeuwkes R 3rd. Lipoic acid analogs with enhanced pharmacological activity. Bioorg Med Chem. 2014 Jan 1;22(1):505-12. doi: 10.1016/j.bmc.2013.10.057. PubMed PMID: 24316353.