MedKoo Cat#: 529322 | Name: Lesopitron dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lesopitron dihydrochloride is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.

Chemical Structure

Lesopitron dihydrochloride
Lesopitron dihydrochloride
CAS#132449-89-9 (Lesopitron HCl)

Theoretical Analysis

MedKoo Cat#: 529322

Name: Lesopitron dihydrochloride

CAS#: 132449-89-9 (Lesopitron HCl)

Chemical Formula: C15H23Cl3N6

Exact Mass:

Molecular Weight: 393.74

Elemental Analysis: C, 45.76; H, 5.89; Cl, 27.01; N, 21.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
132449-46-8 (Lesopitron free base)
Synonym
E-4424; E4424; E 4424
IUPAC/Chemical Name
2-(4-(4-(4-chloro-1H-pyrazol-1-yl)butyl)piperazin-1-yl)pyrimidine dihydrochloride
InChi Key
RGDLQJUAYQRGBC-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H21ClN6.2ClH/c16-14-12-19-22(13-14)7-2-1-6-20-8-10-21(11-9-20)15-17-4-3-5-18-15;;/h3-5,12-13H,1-2,6-11H2;2*1H
SMILES Code
ClC1=CN(CCCCN2CCN(C3=NC=CC=N3)CC2)N=C1.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 393.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Glavin GB, Alvarez I, Colombo M, Farré AJ. Effects of a novel 5-HT1A receptor agonist, E4424, on gastric adherent mucus levels following restraint stress in rats. Dig Dis Sci. 1995 Nov;40(11):2317-20. PubMed PMID: 7587808. 2: Farré AJ, Colombo M, Alvarez I, Glavin GB. Some novel 5-hydroxytryptamine1A (5-HT1A) receptor agonists reduce gastric acid and pepsin secretion, reduce experimental gastric mucosal injury and enhance gastric mucus in rats. J Pharmacol Exp Ther. 1995 Feb;272(2):832-7. PubMed PMID: 7853201. 3: Lanfumey L, Haj-Dahmane S, Hamon M. Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525. Eur J Pharmacol. 1993 Nov 2;249(1):25-35. PubMed PMID: 8282017.