ICA-27243 | CAS#325457-89-4 | Voltage-Gated K+ Channel Activator

MedKoo Cat#: 531964 | Name: ICA-27243

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICA-27243 is a novel, potent and selective activator of M-current and KCNQ2/Q3 channels. ICA-27243 enhances KCNQ channel activation by shifting channel opening to more hyperpolarized potentials.

Chemical Structure

ICA-27243

CAS#325457-89-4

Theoretical Analysis

MedKoo Cat#: 531964

Name: ICA-27243

CAS#: 325457-89-4

Chemical Formula: C12H7ClF2N2O

Exact Mass: 268.0215

Molecular Weight: 268.65

Elemental Analysis: C, 53.65; H, 2.63; Cl, 13.20; F, 14.14; N, 10.43; O, 5.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

ICA-27243; ICA 27243; ICA27243.

IUPAC/Chemical Name

N-(6-chloropyridin-3-yl)-3,4-difluorobenzamide

InChi Key

GDGUOCFTHNGPBK-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18)

SMILES Code

O=C(NC1=CC=C(Cl)N=C1)C2=CC=C(F)C(F)=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 268.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sander SE, Lambrecht C, Richter A. The K(V)7.2/3 preferring channel opener ICA 27243 attenuates L-DOPA-induced dyskinesia in hemiparkinsonian rats. Neurosci Lett. 2013 Jun 17;545:59-63. doi: 10.1016/j.neulet.2013.04.017. PubMed PMID: 23623937. 2: Blom SM, Schmitt N, Jensen HS. Differential effects of ICA-27243 on cloned K(V)7 channels. Pharmacology. 2010;86(3):174-81. doi: 10.1159/000317525. PubMed PMID: 20714208. 3: Padilla K, Wickenden AD, Gerlach AC, McCormack K. The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neurosci Lett. 2009 Nov 13;465(2):138-42. doi: 10.1016/j.neulet.2009.08.071. PubMed PMID: 19733209. 4: Roeloffs R, Wickenden AD, Crean C, Werness S, McNaughton-Smith G, Stables J, McNamara JO, Ghodadra N, Rigdon GC. In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models. J Pharmacol Exp Ther. 2008 Sep;326(3):818-28. doi: 10.1124/jpet.108.137794. PubMed PMID: 18577704. 5: Wickenden AD, Krajewski JL, London B, Wagoner PK, Wilson WA, Clark S, Roeloffs R, McNaughton-Smith G, Rigdon GC. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol. 2008 Mar;73(3):977-86. PubMed PMID: 18089837.