Parthenolide | NSC-157035 | CAS#20554-84-1 | NF-κB Activation Inhibitor

MedKoo Cat#: 527903 | Name: Parthenolide

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Parthenolide, also known as NSC-157035, is a NF-κB activation inhibitor potentially for the treatment of cancer. Parthenolide induces apoptosis and autophagy-mediated growth inhibition in HeLa cells by suppressing the PI3K/Akt signaling pathway and mitochondrial membrane depolarization and ROS generation.

Chemical Structure

Parthenolide

CAS#20554-84-1

Theoretical Analysis

MedKoo Cat#: 527903

Name: Parthenolide

CAS#: 20554-84-1

Chemical Formula: C15H20O3

Exact Mass: 248.1412

Molecular Weight: 248.32

Elemental Analysis: C, 72.55; H, 8.12; O, 19.33

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 150.00
50mg	USD 250.00
100mg	USD 450.00

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Related CAS #

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Synonym

Parthenolide; NSC-157035; NSC 157035; NSC157035

IUPAC/Chemical Name

(3aS,9aR,10aR,10bS,E)-6,9a-dimethyl-3-methylene-3a,4,5,8,9,9a,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-2(3H)-one

InChi Key

KTEXNACQROZXEV-PVLRGYAZSA-N

InChi Code

InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1

SMILES Code

O=C(O[C@@]1([H])[C@@]2([H])CC/C(C)=C/CC[C@]3(C)[C@]1([H])O3)C2=C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 248.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cai Z, Gao L, Hu K, Wang QM. Parthenolide enhances the metronomic chemotherapy effect of cyclophosphamide in lung cancer by inhibiting the NF-kB signaling pathway. World J Clin Oncol. 2024 Jul 24;15(7):895-907. doi: 10.5306/wjco.v15.i7.895. PMID: 39071467; PMCID: PMC11271733. 2: Kim SM, Kim YH, Han GU, Kim SG, Kim BJ, Moon SH, Shin SH, Ryu BY. Elucidating the mechanisms and mitigation strategies for six-phthalate-induced toxicity in male germ cells. Front Cell Dev Biol. 2024 Jul 10;12:1398176. doi: 10.3389/fcell.2024.1398176. PMID: 39050888; PMCID: PMC11266291. 3: Shariat Razavi SA, Vafaei F, Ebrahimi SM, Abbasinezhad-Moud F, Shahini A, Qoorchi Moheb Seraj F, Alavi MS, Fadavieslam A, Ferns GA, Bahrami A. The protective effect of parthenolide in an in vitro model of Parkinson's disease through its regulation of nuclear factor-kappa B and oxidative stress. Mol Biol Rep. 2024 Jul 17;51(1):819. doi: 10.1007/s11033-024-09779-w. PMID: 39017801. 4: Ajiboye BO, Fatoki TH, Akinola OG, Ajeigbe KO, Bamisaye AF, Domínguez-Martín EM, Rijo P, Oyinloye BE. In silico exploration of anti-prostate cancer compounds from differential expressed genes. BMC Urol. 2024 Jul 3;24(1):138. doi: 10.1186/s12894-024-01521-9. PMID: 38956591; PMCID: PMC11221101. 5: Rai D, George S. Computational analysis of ligands from natural products on the cellular targets of combined hepatocellular carcinoma and cholangiocarcinoma. Nat Prod Res. 2024 Jul 1:1-9. doi: 10.1080/14786419.2024.2373960. Epub ahead of print. PMID: 38949792. 6: Dall'Acqua S, Yagi S, Sut S, Uba AI, Ponniya SKM, Koyuncu I, Toprak K, Balos MM, Kaplan A, Çakılcıoğlu U, Zengin G. Combining chemical profiles and biological abilities of different extracts from Tanacetum nitens ( Boiss. & Noë) Grierson using network pharmacology. Arch Pharm (Weinheim). 2024 Jun 14:e2400194. doi: 10.1002/ardp.202400194. Epub ahead of print. PMID: 38877616. 7: Tan L, Qu J, Wang J. Development of novel lysosome-related signatures and their potential target drugs based on bulk RNA-seq and scRNA-seq for diabetic foot ulcers. Hum Genomics. 2024 Jun 11;18(1):62. doi: 10.1186/s40246-024-00629-1. PMID: 38862997; PMCID: PMC11165785. 8: Cilento MA, Sweeney CJ, Butler LM. Spatial transcriptomics in cancer research and potential clinical impact: a narrative review. J Cancer Res Clin Oncol. 2024 Jun 8;150(6):296. doi: 10.1007/s00432-024-05816-0. PMID: 38850363; PMCID: PMC11162383. 9: Alonso-Gordoa T, Goodman M, Vulsteke C, Roubaud G, Zhang J, Parikh M, Piulats JM, Azaro A, James GD, Cavazzina R, Gangl ET, Thompson J, Pouliot G, Kumar R, Sweeney C. A phase II study (AARDVARC) of AZD4635 in combination with durvalumab and cabazitaxel in patients with progressive, metastatic, castration-resistant prostate cancer. ESMO Open. 2024 Jun;9(6):103446. doi: 10.1016/j.esmoop.2024.103446. Epub 2024 Jun 4. PMID: 38838502; PMCID: PMC11190476. 10: Kim SM, Han GU, Kim SG, Moon SH, Shin SH, Ryu BY. Mitigation of benzyl butyl phthalate toxicity in male germ cells with combined treatment of parthenolide, N-acetylcysteine, and 3-methyladenine. Ecotoxicol Environ Saf. 2024 Jul 15;280:116544. doi: 10.1016/j.ecoenv.2024.116544. Epub 2024 Jun 4. PMID: 38838463. 11: Chen X, Zhang T, He YQ, Miao TW, Yin J, Ding Q, Yang M, Chen FY, Zeng HP, Liu J, Zhu Q. NGEF is a potential prognostic biomarker and could serve as an indicator for immunotherapy and chemotherapy in lung adenocarcinoma. BMC Pulm Med. 2024 May 19;24(1):248. doi: 10.1186/s12890-024-03046-1. PMID: 38764064; PMCID: PMC11102621. 12: Shin Y, Kim J, Song Y, Kim S, Kong H. Efficacy of Laurus nobilis L. for Tight Junction Protein Imbalance in Leaky Gut Syndrome. Nutrients. 2024 Apr 23;16(9):1250. doi: 10.3390/nu16091250. PMID: 38732497; PMCID: PMC11085348. 13: Gobrecht P, Gebel J, Leibinger M, Zeitler C, Chen Z, Gründemann D, Fischer D. Cnicin promotes functional nerve regeneration. Phytomedicine. 2024 Jul;129:155641. doi: 10.1016/j.phymed.2024.155641. Epub 2024 Apr 14. PMID: 38718639. 14: Ma L, Li M, Lv J, Yuan Q, Yin X, Lu W, Lin W, Wang P, Cui J, Lv Q, Liu J, Hu L. Design, synthesis, and biological evaluation of novel sesquiterpene lactone derivatives as PKM2 activators with potent anti-ulcerative colitis activities. Eur J Med Chem. 2024 Jun 5;272:116426. doi: 10.1016/j.ejmech.2024.116426. Epub 2024 Apr 23. PMID: 38718622. 15: Shaik RA. Parthenolide alleviates indomethacin-induced gastric ulcer in rats via antioxidant, anti-inflammatory, and antiapoptotic activities. Naunyn Schmiedebergs Arch Pharmacol. 2024 May 4. doi: 10.1007/s00210-024-03110-x. Epub ahead of print. PMID: 38703207. 16: Gu HJ, Kim DY, Shin SH, Rahman MS, Lee HS, Pang MG, Kim JM, Ryu BY. Genome- wide transcriptome analysis reveals that Bisphenol A activates immune responses in skeletal muscle. Environ Res. 2024 Jul 1;252(Pt 3):119034. doi: 10.1016/j.envres.2024.119034. Epub 2024 May 1. PMID: 38701888. 17: Vu QV, Sayama S, Ando M, Kataoka T. Sesquiterpene Lactones Containing an α-Methylene-γ-Lactone Moiety Selectively Down-Regulate the Expression of Tumor Necrosis Factor Receptor 1 by Promoting Its Ectodomain Shedding in Human Lung Adenocarcinoma A549 Cells. Molecules. 2024 Apr 19;29(8):1866. doi: 10.3390/molecules29081866. PMID: 38675685; PMCID: PMC11053566. 18: Petrova M, Miladinova-Georgieva K, Geneva M. Influence of Abiotic and Biotic Elicitors on Organogenesis, Biomass Accumulation, and Production of Key Secondary Metabolites in Asteraceae Plants. Int J Mol Sci. 2024 Apr 10;25(8):4197. doi: 10.3390/ijms25084197. PMID: 38673783; PMCID: PMC11050642. 19: Xu Y, Jiang C. Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p. Genes Environ. 2024 Apr 22;46(1):10. doi: 10.1186/s41021-024-00304-w. PMID: 38649975; PMCID: PMC11036637. 20: Kim SG, Jeon JH, Shin SH, Varias DC, Moon SH, Ryu BY. Inhibition of reactive oxygen species generation by N-Acetyl Cysteine can mitigate male germ cell toxicity induced by bisphenol analogs. Food Chem Toxicol. 2024 Jun;188:114652. doi: 10.1016/j.fct.2024.114652. Epub 2024 Apr 6. PMID: 38583502.