GSK579289A is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM). It is selective for Plk1 over Plk3 (IC50 = 630 nM). GSK579289A inhibits proliferation of HCT116 cells (IC50 = 11 nM).
MedKoo Cat#: 531884
Name: GSK579289A
CAS#: 929095-23-8
Chemical Formula: C26H27ClN4O3S
Exact Mass: 510.1492
Molecular Weight: 511.04
Elemental Analysis: C, 61.11; H, 5.33; Cl, 6.94; N, 10.96; O, 9.39; S, 6.27
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.0 | 48.92 |
The following data is based on the product molecular weight 511.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
