MedKoo Cat#: 530516 | Name: YKL-04-085

Description:

WARNING: This product is for research use only, not for human or veterinary use.

YKL-04-085 is a potent inhibitor of viral translation and exhibits cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation. YKL-04-085 demonstrated good inhibition of translation of the DENV2(GVD) reporter replicon in cellulo.

Chemical Structure

YKL-04-085
YKL-04-085
CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 530516

Name: YKL-04-085

CAS#: Unknown

Chemical Formula: C30H29N5O2

Exact Mass: 491.2321

Molecular Weight: 491.60

Elemental Analysis: C, 73.30; H, 5.95; N, 14.25; O, 6.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
YKL-04-085; YKL04-085; YKL 04-085; YKL-04085; YKL04085; YKL 04085.
IUPAC/Chemical Name
(E)-4-(dimethylamino)-N-(2-methyl-5-(9-(1-methyl-1H-pyrazol-4-yl)-2-oxobenzo[h]quinolin-1(2H)-yl)phenyl)but-2-enamide
InChi Key
JNHXDBIEQOIKLK-AATRIKPKSA-N
InChi Code
InChI=1S/C30H29N5O2/c1-20-7-13-25(17-27(20)32-28(36)6-5-15-33(2)3)35-29(37)14-12-22-10-8-21-9-11-23(16-26(21)30(22)35)24-18-31-34(4)19-24/h5-14,16-19H,15H2,1-4H3,(H,32,36)/b6-5+
SMILES Code
O=C1N(C2=CC(NC(/C=C/CN(C)C)=O)=C(C=C2)C)C3=C(C=CC4=CC=C(C5=CN(C)N=C5)C=C43)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 491.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Structure–Activity Relationship Study of QL47: A Broad-Spectrum Antiviral Agent Yanke LiangMelissanne de WispelaereMargot CarocciQingsong LiuJinhua WangPriscilla L. YangNathanael S. Gray Publication Date (Web): February 3, 2017 (Letter) DOI: 10.1021/acsmedchemlett.7b00008