GSK931145 | CAS# 896117-64-9 | GlyT1 inhibitor

MedKoo Cat#: 531878 | Name: GSK931145

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK931145 is a newly developed positron emission tomography (PET) radioligand suitable for quantifying glycine transporter (GlyT1) availability in the living brain.

Chemical Structure

GSK931145

CAS#896117-64-9

Theoretical Analysis

MedKoo Cat#: 531878

Name: GSK931145

CAS#: 896117-64-9

Chemical Formula: C23H30N2O

Exact Mass: 350.2358

Molecular Weight: 350.51

Elemental Analysis: C, 78.82; H, 8.63; N, 7.99; O, 4.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GSK931145; GSK 931145; GSK-931145

IUPAC/Chemical Name

N-((1-(dimethylamino)cyclopentyl)(phenyl)methyl)-2,6-dimethylbenzamide

InChi Key

BMXRRRIDMAIEKX-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H30N2O/c1-17-11-10-12-18(2)20(17)22(26)24-21(19-13-6-5-7-14-19)23(25(3)4)15-8-9-16-23/h5-7,10-14,21H,8-9,15-16H2,1-4H3,(H,24,26)

SMILES Code

CC1=C(C(=CC=C1)C)C(=O)NC(C2=CC=CC=C2)C3(CCCC3)N(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 350.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zheng MQ, Lin SF, Holden D, Naganawa M, Ropchan JR, Najafzaden S, Kapinos M, Tabriz M, Carson RE, Hamill TG, Huang Y. Comparative evaluation of two glycine transporter 1 radiotracers [11C]GSK931145 and [18F]MK-6577 in baboons. Synapse. 2016 Mar;70(3):112-20. doi: 10.1002/syn.21879. PubMed PMID: 26671330. 2: Chopra A. (11)C-Labeled GSK931145. 2012 Mar 2 [updated 2012 Apr 19]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK92277/ PubMed PMID: 22536614. 3: Gunn RN, Murthy V, Catafau AM, Searle G, Bullich S, Slifstein M, Ouellet D, Zamuner S, Herance R, Salinas C, Pardo-Lozano R, Rabiner EA, Farre M, Laruelle M. Translational characterization of [11C]GSK931145, a PET ligand for the glycine transporter type 1. Synapse. 2011 Dec;65(12):1319-32. doi: 10.1002/syn.20966. PubMed PMID: 21688322. 4: Bullich S, Slifstein M, Passchier J, Murthy NV, Kegeles LS, Kim JH, Xu X, Gunn RN, Herance R, Gispert JD, Gutiérrez A, Farré M, Laruelle M, Catafau AM. Biodistribution and radiation dosimetry of the glycine transporter-1 ligand 11C-GSK931145 determined from primate and human whole-body PET. Mol Imaging Biol. 2011 Aug;13(4):776-84. doi: 10.1007/s11307-010-0398-6. PubMed PMID: 20730499. 5: Passchier J, Gentile G, Porter R, Herdon H, Salinas C, Jakobsen S, Audrain H, Laruelle M, Gunn RN. Identification and evaluation of [11C]GSK931145 as a novel ligand for imaging the type 1 glycine transporter with positron emission tomography. Synapse. 2010 Jul;64(7):542-9. doi: 10.1002/syn.20760. PubMed PMID: 20196141.