ZED-1227 is a selective transglutaminase 2 (TG2) inhibitor developed for the treatment of celiac disease. It blocks TG2-mediated gluten peptide crosslinking and deamidation, which are key steps in triggering the autoimmune response in celiac patients. ZED-1227 has shown potential to reduce intestinal inflammation and tissue damage by limiting gluten-induced immune activation while preserving normal TG2 functions.
MedKoo Cat#: 527713
Name: ZED-1227
CAS#: 1542132-88-6
Chemical Formula: C26H36N6O6
Exact Mass: 528.2696
Molecular Weight: 528.61
Elemental Analysis: C, 59.08; H, 6.86; N, 15.90; O, 18.16
The following data is based on the product molecular weight 528.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
