NEU-1923 | CAS# | inhibitor of T. brucei proliferation

MedKoo Cat#: 530514 | Name: NEU-1923

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NEU-1923 is a potent inhibitor of T. brucei proliferation with improved drug-like properties (EC50= 0.37 μM). Human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis present a significant burden across the developing world. Existing therapeutics for these protozoal neglected tropical diseases suffer from severe side effects and toxicity.

Chemical Structure

NEU-1923

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 530514

Name: NEU-1923

CAS#: Unknown

Chemical Formula: C23H20ClN5O3S

Exact Mass: 481.0975

Molecular Weight: 481.96

Elemental Analysis: C, 57.32; H, 4.18; Cl, 7.36; N, 14.53; O, 9.96; S, 6.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

NEU-1923; NEU-1923; NEU-1923.

IUPAC/Chemical Name

N-(5-chloropyrimidin-2-yl)-6-(4-(morpholinosulfonyl)phenyl)quinolin-4-amine

InChi Key

QQORJONSENOSNM-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H20ClN5O3S/c24-18-14-26-23(27-15-18)28-22-7-8-25-21-6-3-17(13-20(21)22)16-1-4-19(5-2-16)33(30,31)29-9-11-32-12-10-29/h1-8,13-15H,9-12H2,(H,25,26,27,28)

SMILES Code

O=S(C1=CC=C(C2=CC=C3N=CC=C(NC4=NC=C(Cl)C=N4)C3=C2)C=C1)(N5CCOCC5)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Taken together, human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis are responsible for 4.4 million disability adjusted life years (DALY) and 70,000 deaths annually.1 Caused by the protozoan parasites Trypanosoma brucei, T. cruzi, and Leishmania spp., respectively, these diseases are spread through insect vectors across Latin America, Africa, and parts of southern Asia.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 481.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites William DevineSarah M. ThomasJessey ErathKelly A. BachovchinPatricia J. LeeSusan E. LeedAna RodriguezRichard J. SciottiKojo Mensa-Wilmotand Michael P. Pollastri Publication Date (Web): February 5, 2017 (Letter) DOI: 10.1021/acsmedchemlett.7b00011