Synonym
FR190997; FR 190997; FR-190997.
IUPAC/Chemical Name
4-[(E)-3-[[2-[[2,4-dichloro-3-[[2-methyl-4-(pyridin-2-ylmethoxy)quinolin-8-yl]oxymethyl]phenyl]-methylamino]-2-oxoethyl]amino]-3-oxoprop-1-enyl]-N-methylbenzamide
InChi Key
YFMDLMSUZMRKKH-SFQUDFHCSA-N
InChi Code
InChI=1S/C37H33Cl2N5O5/c1-23-19-32(48-21-26-7-4-5-18-41-26)27-8-6-9-31(36(27)43-23)49-22-28-29(38)15-16-30(35(28)39)44(3)34(46)20-42-33(45)17-12-24-10-13-25(14-11-24)37(47)40-2/h4-19H,20-22H2,1-3H3,(H,40,47)(H,42,45)/b17-12+
SMILES Code
O=C(NC)C1=CC=C(/C=C/C(NCC(N(C2=CC=C(Cl)C(COC3=C4N=C(C)C=C(OCC5=NC=CC=C5)C4=CC=C3)=C2Cl)C)=O)=O)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
698.60
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bellucci F, Meini S, Cucchi P, Catalani C, Reichert W, Zappitelli S, Rotondaro L, Quartara L, Giolitti A, Maggi CA. A different molecular interaction of bradykinin and the synthetic agonist FR190997 with the human B2 receptor: evidence from mutational analysis. Br J Pharmacol. 2003 Oct;140(3):500-6. PubMed PMID: 12970081; PubMed Central PMCID: PMC1574048.
2: Hayashi I, Ishihara K, Kumagai Y, Majima M. Proinflammatory characteristics of a nonpeptide bradykinin mimic, FR190997, in vivo. Br J Pharmacol. 2001 Aug;133(8):1296-306. PubMed PMID: 11498515; PubMed Central PMCID: PMC1621159.
3: Cuthbert AW. Anion secretory effects of a non-peptide mimic of bradykinin (FR190997) on mouse colon epithelium. Immunopharmacology. 1999 Dec;45(1-3):191-8. PubMed PMID: 10615011.
4: Ueno A, Naraba H, Kojima F, Morita E, Oh-ishi S. FR190997, a novel bradykinin B2 agonist, expresses longer action than bradykinin in paw edema formation and hypotensive response. Immunopharmacology. 1999 Dec;45(1-3):89-93. PubMed PMID: 10614995.
5: Asano M, Hatori C, Sawai H, Johki S, Inamura N, Kayakiri H, Satoh S, Abe Y, Inoue T, Sawada Y, Mizutani T, Oku T, Nakahara K. Pharmacological characterization of a nonpeptide bradykinin B2 receptor antagonist, FR165649, and agonist, FR190997. Br J Pharmacol. 1998 Jun;124(3):441-6. PubMed PMID: 9647466; PubMed Central PMCID: PMC1565402.
