GRI918013 | CAS#313685-55-1 | ATX inhibitor

MedKoo Cat#: 530499 | Name: GRI918013

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GRI918013 is a ATX inhibitor. Autotaxin (ATX) inhibitors represent an emerging class of drug candidates with therapeutic potential in the treatment of disease conditions that include cancer, cardiovascular disease, chronic inflammation, and neuropathic pain.

Chemical Structure

GRI918013

CAS#313685-55-1

Theoretical Analysis

MedKoo Cat#: 530499

Name: GRI918013

CAS#: 313685-55-1

Chemical Formula: C17H15Cl2FN2O4S

Exact Mass: 432.0114

Molecular Weight: 433.28

Elemental Analysis: C, 47.13; H, 3.49; Cl, 16.36; F, 4.38; N, 6.47; O, 14.77; S, 7.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

GRI918013; GRI-918013; GRI 918013.

IUPAC/Chemical Name

2,4-dichloro-N-(3-fluorophenyl)-5-(morpholinosulfonyl)benzamide

InChi Key

WFSFEJJQFJYRFU-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H15Cl2FN2O4S/c18-14-10-15(19)16(27(24,25)22-4-6-26-7-5-22)9-13(14)17(23)21-12-3-1-2-11(20)8-12/h1-3,8-10H,4-7H2,(H,21,23)

SMILES Code

O=C(NC1=CC=CC(F)=C1)C2=CC(S(=O)(N3CCOCC3)=O)=C(Cl)C=C2Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Modulation of autotaxin (ATX), the lysophospholipase D enzyme that produces lysophosphatidic acid, with small-molecule inhibitors is a promising strategy for blocking the ATX-lysophosphatidic acid signaling axis.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 433.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Fells, James I.; Lee, Sue Chin; Norman, Derek D.; Tsukahara, Ryoko; Kirby, Jason R.; Nelson, Sandra; Seibel, William; Papoian, Ruben; Patil, Renukadevi; Miller, Duane D.; et al. Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif. FEBS Journal (2014), 281(4), 1017-1028. 2. Fells, James I.; Lee, Sue Chin; Fujiwara, Yuko; Norman, Derek D.; Lim, Keng Gat; Tsukahara, Ryoko; Liu, Jianxiong; Patil, Renukadevi; Miller, Duane D.; Kirby, R. Jason; et al. Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface. Molecular Pharmacology (2013), 84(3), 415-424.