CP-775146 | CAS#702680-17-9 | PPARα agonist

MedKoo Cat#: 531747 | Name: CP-775146

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-775146 is a selective, high affinity PPARα agonist. CP-775146 exhibits hypolipidemic activity in vivo.

Chemical Structure

CP-775146

CAS#702680-17-9

Theoretical Analysis

MedKoo Cat#: 531747

Name: CP-775146

CAS#: 702680-17-9

Chemical Formula: C26H33NO4

Exact Mass: 423.2410

Molecular Weight: 423.55

Elemental Analysis: C, 73.73; H, 7.85; N, 3.31; O, 15.11

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	2 Weeks
25mg	USD 950.00	2 Weeks

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Related CAS #

No Data

Synonym

CP-775146; CP 775146; CP775146;

IUPAC/Chemical Name

2-methyl-2-[3-[(3S)-1-[2-(4-propan-2-ylphenyl)acetyl]piperidin-3-yl]phenoxy]propanoic acid

InChi Key

OISHBINQIFNIPV-JOCHJYFZSA-N

InChi Code

InChI=1S/C26H33NO4/c1-18(2)20-12-10-19(11-13-20)15-24(28)27-14-6-8-22(17-27)21-7-5-9-23(16-21)31-26(3,4)25(29)30/h5,7,9-13,16,18,22H,6,8,14-15,17H2,1-4H3,(H,29,30)/t22-/m1/s1

SMILES Code

CC(OC1=CC=CC([C@H]2CN(C(CC3=CC=C(C(C)C)C=C3)=O)CCC2)=C1)(C)C(O)=O

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Selective, high affinity PPARα agonist.

In vitro activity:

TBD

In vivo activity:

CP775146 increased the liver weight but did not affect the on mean body weight (Figures 1(a) and 1(b)). At >0.3 mg/kg, CP775146 significantly increased the serum alanine aminotransferase (ALT) level (a measure of liver function, Figure 1(c)) but not that of aspartate aminotransferase (AST, Figure 1(d)). Reference: J Diabetes Res. 2020; 2020: 4179852. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222497/

	Solvent	mg/mL	mM
Solubility
	DMSO	42.4	99.99

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 423.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Tang S, Wu F, Lin X, Gui W, Zheng F, Li H. The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism. J Diabetes Res. 2020 May 4;2020:4179852. doi: 10.1155/2020/4179852. PMID: 32455134; PMCID: PMC7222497.

In vitro protocol:

TBD

In vivo protocol:

1. Kane et al (2009) Molecular characterization of novel and selective peroxisome proliferator-activated receptor α agonists with robust hypolipidemic activity in vivo. Mol.Pharmacol. 75 296. PMID: 18971326.