CI-1015 | CAS# 156672-01-4 | CCK-B receptor antagonist

MedKoo Cat#: 513690 | Name: CI-1015

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CI-1015 is an orally active CCK-B receptor antagonist.

Chemical Structure

CI-1015

CAS#156672-01-4

Theoretical Analysis

MedKoo Cat#: 513690

Name: CI-1015

CAS#: 156672-01-4

Chemical Formula: C29H39N3O4

Exact Mass: 493.2941

Molecular Weight: 493.65

Elemental Analysis: C, 70.56; H, 7.96; N, 8.51; O, 12.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

CI-1015; CI 1015; CI1015; PD 144598.

IUPAC/Chemical Name

1-adamantyl N-[(2R)-1-[[(1S,2S)-2-hydroxycyclohexyl]amino]-3-(1H-indol-3-yl)-2-methyl-1-oxopropan-2-yl]carbamate

InChi Key

UOFRODPUIMDZTB-HDCXSGMISA-N

InChi Code

InChI=1S/C29H39N3O4/c1-28(26(34)31-24-8-4-5-9-25(24)33,16-21-17-30-23-7-3-2-6-22(21)23)32-27(35)36-29-13-18-10-19(14-29)12-20(11-18)15-29/h2-3,6-7,17-20,24-25,30,33H,4-5,8-16H2,1H3,(H,31,34)(H,32,35)/t18?,19?,20?,24-,25-,28+,29?/m0/s1

SMILES Code

O=C(OC12CC3CC(C2)CC(C3)C1)N[C@@](CC4=CNC5=C4C=CC=C5)(C)C(N[C@@H]6[C@@H](O)CCCC6)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 493.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kayser V, Viguier F, Ioannidi M, Bernard JF, Latrémolière A, Michot B, Vela JM, Buschmann H, Hamon M, Bourgoin S. Differential anti-neuropathic pain effects of tetrodotoxin in sciatic nerve- versus infraorbital nerve-ligated rats--behavioral, pharmacological and immunohistochemical investigations. Neuropharmacology. 2010 Feb;58(2):474-87. doi: 10.1016/j.neuropharm.2009.09.003. PubMed PMID: 19747496. 2: Trivedi BK, Hinton JP. CI-1015. An orally active CCK-B receptor antagonist with an improved pharmacokinetic profile. Pharm Biotechnol. 1998;11:481-505. Review. PubMed PMID: 9760693. 3: Trivedi BK, Padia JK, Holmes A, Rose S, Wright DS, Hinton JP, Pritchard MC, Eden JM, Kneen C, Webdale L, Suman-Chauhan N, Boden P, Singh L, Field MJ, Hill D. Second generation "peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile. J Med Chem. 1998 Jan 1;41(1):38-45. PubMed PMID: 9438020.