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MedKoo Cat#: 513687 | Name: CGS8216

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGS8216 is a benzodiazepine receptor antagonist. CGS8216 is an anxiolytic pyrazoloquinoline.

Chemical Structure

CGS8216
CGS8216
CAS#77779-60-3

Theoretical Analysis

MedKoo Cat#: 513687

Name: CGS8216

CAS#: 77779-60-3

Chemical Formula: C16H11N3O

Exact Mass: 261.0902

Molecular Weight: 261.28

Elemental Analysis: C, 73.55; H, 4.24; N, 16.08; O, 6.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CGS8216; CGS 8216; CGS-8216.
IUPAC/Chemical Name
2-phenyl-1H,2H,3H-pyrazolo[4,3-c]quinolin-3-one
InChi Key
XTYGFVVANLMBHE-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H11N3O/c20-16-13-10-17-14-9-5-4-8-12(14)15(13)18-19(16)11-6-2-1-3-7-11/h1-10,18H
SMILES Code
O=C1N(C2=CC=CC=C2)NC3=C1C=NC4=CC=CC=C34
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 261.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Maier SF, Grahn RE, Maswood S, Watkins LR. The benzodiazepine receptor antagonists flumazenil and CGS8216 block the enhancement of fear conditioning and interference with escape behavior produced by inescapable shock. Psychopharmacology (Berl). 1995 Sep;121(2):250-8. PubMed PMID: 8545531. 2: Shannon HE, Davis SL. CGS8216 noncompetitively antagonizes the discriminative effects of diazepam in rats. Life Sci. 1984 Jun 25;34(26):2589-96. PubMed PMID: 6738298.