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MedKoo Cat#: 513685 | Name: CGS 15943
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGS 15943 is a potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively).

Chemical Structure

CGS 15943
CGS 15943
CAS#104615-18-1

Theoretical Analysis

MedKoo Cat#: 513685

Name: CGS 15943

CAS#: 104615-18-1

Chemical Formula: C13H8ClN5O

Exact Mass: 285.0417

Molecular Weight: 285.69

Elemental Analysis: C, 54.65; H, 2.82; Cl, 12.41; N, 24.51; O, 5.60

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
CGS 15943; CGS15943; CGS-15943; CGS 15943A; CGS15943A; CGS-15943A;
IUPAC/Chemical Name
9-chloro-2-furan-2-yl-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
InChi Key
MSJODEOZODDVGW-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)
SMILES Code
NC1=NC2=C(C=C(Cl)C=C2)C3=NC(C4=CC=CO4)=NN13
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 285.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Edling CE, Selvaggi F, Ghonaim R, Maffucci T, Falasca M. Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway. Cancer Biol Ther. 2014 May;15(5):524-32. doi: 10.4161/cbt.28018. PubMed PMID: 24521981; PubMed Central PMCID: PMC4026075. 2: Holtzman SG. Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, have a dopamine component in monkeys. Eur J Pharmacol. 1999 Jul 2;376(1-2):7-15. PubMed PMID: 10440083. 3: Ongini E, Dionisotti S, Gessi S, Irenius E, Fredholm BB. Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol. 1999 Jan;359(1):7-10. PubMed PMID: 9933143. 4: Kim YC, de Zwart M, Chang L, Moro S, von Frijtag Drabbe Künzel JK, Melman N, IJzerman AP, Jacobson KA. Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes. J Med Chem. 1998 Jul 16;41(15):2835-45. PubMed PMID: 9667972. 5: Holtzman SG. Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, in monkeys: comparison to methylxanthines. J Pharmacol Exp Ther. 1996 May;277(2):739-46. PubMed PMID: 8627553. 6: Imaizumi M, Miyazaki S, Onodera K. Effects of a non-xanthine adenosine antagonist, CGS 15943, and a phosphodiesterase inhibitor, Ro 20-1724, in a light/dark test in mice. Methods Find Exp Clin Pharmacol. 1994 Dec;16(10):717-21. PubMed PMID: 7723470. 7: Gao Y, Phillis JW. CGS 15943, an adenosine A2 receptor antagonist, reduces cerebral ischemic injury in the Mongolian gerbil. Life Sci. 1994;55(3):PL61-5. PubMed PMID: 8007757. 8: Howell LL, Byrd LD. Effects of CGS 15943, a nonxanthine adenosine antagonist, on behavior in the squirrel monkey. J Pharmacol Exp Ther. 1993 Oct;267(1):432-9. PubMed PMID: 8229772. 9: Jarvis MF, Williams M, Do UH, Sills MA. Characterization of the binding of a novel nonxanthine adenosine antagonist radioligand, [3H]CGS 15943, to multiple affinity states of the adenosine A1 receptor in the rat cortex. Mol Pharmacol. 1991 Jan;39(1):49-54. PubMed PMID: 1987452. 10: Czuczwar SJ, Janusz W, Szczepanik B, Kleinrok Z. Influence of CGS 15943 A (a nonxanthine adenosine antagonist) on the protection offered by a variety of antiepileptic drugs against maximal electroshock-induced seizures in mice. J Neural Transm Gen Sect. 1991;86(2):127-34. PubMed PMID: 1953988. 11: Holtzman SG. CGS 15943, a nonxanthine adenosine receptor antagonist: effects on locomotor activity of nontolerant and caffeine-tolerant rats. Life Sci. 1991;49(21):1563-70. PubMed PMID: 1943461. 12: Williams M, Francis J, Ghai G, Braunwalder A, Psychoyos S, Stone GA, Cash WD. Biochemical characterization of the triazoloquinazoline, CGS 15943, a novel, non-xanthine adenosine antagonist. J Pharmacol Exp Ther. 1987 May;241(2):415-20. PubMed PMID: 2883298.