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MedKoo Cat#: 513673 | Name: CGP 46381

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP 46381 is a brain penetrant, selective GABAB receptor antagonist (IC50 = 4.9 μM).

Chemical Structure

CGP 46381
CGP 46381
CAS#123691-14-5

Theoretical Analysis

MedKoo Cat#: 513673

Name: CGP 46381

CAS#: 123691-14-5

Chemical Formula: C10H22NO2P

Exact Mass: 219.1388

Molecular Weight: 219.26

Elemental Analysis: C, 54.78; H, 10.11; N, 6.39; O, 14.59; P, 14.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CGP 46381; CGP46381; CGP-46381.
IUPAC/Chemical Name
3-aminopropyl-(cyclohexylmethyl)phosphinic acid
InChi Key
XOESDNIUAWGCLU-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H22NO2P/c11-7-4-8-14(12,13)9-10-5-2-1-3-6-10/h10H,1-9,11H2,(H,12,13)
SMILES Code
O=P(CC1CCCCC1)(CCCN)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 219.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ishige K, Endo H, Saito H, Ito Y. Repeated administration of CGP 46381, a gamma-aminobutyric acidB antagonist, and ethosuximide suppresses seizure-associated cyclic adenosine 3'5' monophosphate response element- and activator protein-1 DNA-binding activities in lethargic (lh/lh) mice. Neurosci Lett. 2001 Jan 19;297(3):207-10. PubMed PMID: 11137764.