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MedKoo Cat#: 513669 | Name: CGP-35348
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP-35348 is a selective GABA_B receptor antagonist that has been widely used in preclinical studies to investigate the role of GABA_B signaling in cognitive and neurological functions. It competitively inhibits GABA_B receptors with an affinity (Ki) in the low micromolar range—reported values vary but typically fall around 3–20 µM depending on assay and tissue. In vivo, CGP-35348 has been shown to improve memory performance in rodent models, particularly in tasks like the Morris water maze and passive avoidance, suggesting a role for GABA_B inhibition in enhancing cognitive function. Additionally, CGP-35348 can modulate seizure thresholds and alter locomotor activity, further supporting its impact on central nervous system excitability.

Chemical Structure

CGP-35348
CGP-35348
CAS#123690-79-9

Theoretical Analysis

MedKoo Cat#: 513669

Name: CGP-35348

CAS#: 123690-79-9

Chemical Formula: C8H20NO4P

Exact Mass: 225.1130

Molecular Weight: 225.22

Elemental Analysis: C, 42.66; H, 8.95; N, 6.22; O, 28.41; P, 13.75

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
50mg USD 1,250.00 2 Weeks
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Related CAS #
No Data
Synonym
CGP 35348; CGP35348; CGP-35348.
IUPAC/Chemical Name
3-aminopropyl-(diethoxymethyl)phosphinic acid
InChi Key
QIIVUOWTHWIXFO-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11)
SMILES Code
O=P(C(OCC)OCC)(CCCN)O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 225.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gillani Q, Ali M, Iqbal F. Effect of GABA(B) receptor antagonists (CGP 35348 and CGP 55845) on serum interleukin 6 and 18 concentrations in albino mice following neonatal hypoxia ischemia insult. Pak J Pharm Sci. 2016 Sep;29(5):1503-1508. PubMed PMID: 27731803. 2: Gillani Q, Ali M, Iqbal F. CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res Int. 2014;2014:295215. doi: 10.1155/2014/295215. PubMed PMID: 24804211; PubMed Central PMCID: PMC3997133. 3: Mareš P. GABA-B receptor antagonist CGP 35348 interferes with an arrest of cortical epileptic afterdischarges in developing rats. Epilepsy Res. 2010 Dec;92(2-3):125-33. doi: 10.1016/j.eplepsyres.2010.08.011. PubMed PMID: 20863662. 4: Patel SM, Ebenezer IS. The effects of intraperitoneal and intracerebroventricular administration of the GABAB receptor antagonist CGP 35348 on food intake in rats. Eur J Pharmacol. 2004 Oct 25;503(1-3):89-93. PubMed PMID: 15496301. 5: Ritchie GD, Hulme ME, Rossi J 3rd. Treatment of spontaneous and chemically induced EEG paroxysms in the Fischer-344 rat with traditional antiepileptic drugs or AED+CGP 35348 polytherapy. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Aug;27(5):847-62. PubMed PMID: 12921919. 6: Vinay L, Clarac F. CGP 35348 and CGP 55845A block the baclofen-induced depression of dorsal root evoked potentials in lumbar motoneurons of the neonatal rat. Neurosci Lett. 1996 Aug 23;214(2-3):103-6. PubMed PMID: 8878094. 7: Smith KA, Fisher RS. The selective GABAB antagonist CGP-35348 blocks spike-wave bursts in the cholesterol synthesis rat absence epilepsy model. Brain Res. 1996 Aug 12;729(2):147-50. PubMed PMID: 8876982. 8: Thomas DA, Navarrete IM, Graham BA, McGowan MK, Hammond DL. Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats. Brain Res. 1996 Apr 29;718(1-2):129-37. PubMed PMID: 8773775. 9: Nissbrandt H, Engberg G. The GABAB-receptor antagonist, CGP 35348, antagonises gamma-hydroxybutyrate- and baclofen-induced alterations in locomotor activity and forebrain dopamine levels in mice. J Neural Transm (Vienna). 1996;103(11):1255-63. PubMed PMID: 9013412. 10: Puigcerver A, van Luijtelaar EL, Drinkenburg WH, Coenen AL. Effects of the GABAB antagonist CGP 35348 on sleep-wake states, behaviour, and spike-wave discharges in old rats. Brain Res Bull. 1996;40(3):157-62. PubMed PMID: 8736575. 11: Chowdhury SA, Kawashima T, Konishi T, Niwa M, Matsunami K. GABAB receptor antagonist CGP 35348 shortens transcallosal response latency of pyramidal tract neurons. Eur J Pharmacol. 1995 Oct 4;285(1):99-102. PubMed PMID: 8846817. 12: Niklasson M, Stengård K, Tham R. Are the effects of toluene on the vestibulo and opto-ocular motor system inhibited by the action of GABAB antagonist CGP 35348? Neurotoxicol Teratol. 1995 May-Jun;17(3):351-7. PubMed PMID: 7623742. 13: Paredes RG, Agmo A. The GABAB antagonist CGP 35348 inhibits the effects of baclofen on sexual behavior and motor coordination. Brain Res Bull. 1995;36(5):495-7. PubMed PMID: 7712213. 14: Hao JX, Xu XJ, Wiesenfeld-Hallin Z. Intrathecal gamma-aminobutyric acidB (GABAB) receptor antagonist CGP 35348 induces hypersensitivity to mechanical stimuli in the rat. Neurosci Lett. 1994 Dec 5;182(2):299-302. PubMed PMID: 7715832. 15: Schlicker E, Malinowska B, Kathmann M. CGP 35348 blocks noradrenaline-release-inhibiting GABAB receptors in the pig retina, rat vena cava and pithed rat vasculature. Pharmacology. 1993 Aug;47(2):111-6. PubMed PMID: 8395059. 16: Hammond DL, Washington JD. Antagonism of L-baclofen-induced antinociception by CGP 35348 in the spinal cord of the rat. Eur J Pharmacol. 1993 Apr 6;234(2-3):255-62. PubMed PMID: 8387011. 17: Bianchi M, Panerai AE. Reversal of scopolamine-induced amnesia by the GABAB receptor antagonist CGP 35348 in the mouse. Brain Res Cogn Brain Res. 1993 Apr;1(2):135-6. PubMed PMID: 8390321. 18: Brucato FH, Morrisett RA, Wilson WA, Swartzwelder HS. The GABAB receptor antagonist, CGP-35348, inhibits paired-pulse disinhibition in the rat dentate gyrus in vivo. Brain Res. 1992 Aug 14;588(1):150-3. PubMed PMID: 1327407. 19: Malcangio M, Malmberg-Aiello P, Giotti A, Ghelardini C, Bartolini A. Desensitization of GABAB receptors and antagonism by CGP 35348, prevent bicuculline- and picrotoxin-induced antinociception. Neuropharmacology. 1992 Aug;31(8):783-91. PubMed PMID: 1326728. 20: Waldmeier PC, Stöcklin K, Feldtrauer JJ. Systemic administration of baclofen and the GABAB antagonist, CGP 35348, does not affect GABA, glutamate or aspartate in microdialysates of the striatum of conscious rats. Naunyn Schmiedebergs Arch Pharmacol. 1992 May;345(5):548-52. PubMed PMID: 1356233.

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