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MedKoo Cat#: 531666 | Name: CD666

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CD 2665 is a retinoic acid receptor β (RARβ) / RARγ antagonist with binding Kd values of 306 nM and 110 nM to RARβ and RARγ.

Chemical Structure

CD666
CAS#170355-78-9

Theoretical Analysis

MedKoo Cat#: 531666

Name: CD666

CAS#: 170355-78-9

Chemical Formula: C24H28O3

Exact Mass: 364.2038

Molecular Weight: 364.49

Elemental Analysis: C, 79.09; H, 7.74; O, 13.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CD666; CD 666; CD-666.
IUPAC/Chemical Name
4-[(E)-3-hydroxy-3-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]benzoic acid
InChi Key
QCSYBKHFYYISTQ-KPKJPENVSA-N
InChi Code
InChI=1S/C24H28O3/c1-23(2)13-14-24(3,4)20-15-18(10-11-19(20)23)21(25)12-7-16-5-8-17(9-6-16)22(26)27/h5-12,15,21,25H,13-14H2,1-4H3,(H,26,27)/b12-7+
SMILES Code
O=C(O)C1=CC=C(/C=C/C(O)C2=CC=C3C(C)(C)CCC(C)(C)C3=C2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 364.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Million K, Tournier F, Houcine O, Ancian P, Reichert U, Marano F. Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation. Am J Respir Cell Mol Biol. 2001 Dec;25(6):744-50. PubMed PMID: 11726401. 2: Chung JJ, Cho S, Kwon YK, Kim DH, Kim K. Activation of retinoic acid receptor gamma induces proliferation of immortalized hippocampal progenitor cells. Brain Res Mol Brain Res. 2000 Nov 10;83(1-2):52-62. PubMed PMID: 11072095. 3: Klaholz BP, Mitschler A, Moras D. Structural basis for isotype selectivity of the human retinoic acid nuclear receptor. J Mol Biol. 2000 Sep 8;302(1):155-70. PubMed PMID: 10964567. 4: Widschwendter M, Daxenbichler G, Culig Z, Michel S, Zeimet AG, Mörtl MG, Widschwendter A, Marth C. Activity of retinoic acid receptor-gamma selectively binding retinoids alone and in combination with interferon-gamma in breast cancer cell lines. Int J Cancer. 1997 May 2;71(3):497-504. PubMed PMID: 9139890.