Related CAS #
172041-16-6 (Imidol free base)
IUPAC/Chemical Name
ethyl 6-bromo-5-hydroxy-1-methyl-2-((phenylsulfinyl)methyl)-1H-indole-3-carboxylate hydrochloride
InChi Key
RMUDTEUUEJZZRY-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18BrNO4S.ClH/c1-3-25-19(23)18-13-9-17(22)14(20)10-15(13)21(2)16(18)11-26(24)12-7-5-4-6-8-12;/h4-10,22H,3,11H2,1-2H3;1H
SMILES Code
O=C(C1=C(CS(C2=CC=CC=C2)=O)N(C)C3=C1C=C(O)C(Br)=C3)OCC.[H]Cl
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
472.77
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liu Z, Peng Y, Ma B, Bi K, Liu Y, Sun G, Ping G, Guo Y. A pharmacokinetic study on a novel anti-HBV agent imidol hydrochloride in rats. Int J Pharm. 2014 Jan 30;461(1-2):514-8. doi: 10.1016/j.ijpharm.2013.12.002. PubMed PMID: 24333907.
2: Shi Z, Bi K, Li Y, Hu X, Li K, Gong P, Chen X. Determination of imidol hydrochloride in human plasma and urine by high-performance liquid chromatography-tandem mass spectrometry and its application to clinical pharmacokinetic study. Biomed Chromatogr. 2012 Apr;26(4):458-63. PubMed PMID: 22493789.
3: Hunoor RS, Patil BR, Badiger DS, Vadavi RS, Gudasi KB, Chandrashekhar VM, Muchchandi IS. Spectroscopic, magnetic and thermal studies of Co(II), Ni(II), Cu(II) and Zn(II) complexes of 3-acetylcoumarin-isonicotinoylhydrazone and their antimicrobial and anti-tubercular activity evaluation. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Nov;77(4):838-44. doi: 10.1016/j.saa.2010.08.015. PubMed PMID: 20833102.
4: Pihlaja K, Martiskainen O, Stájer G. Does the electron ionization induced fragmentation of partly saturated stereoisomeric pyrrolo- and isoindoloquinazolinones show stereospecificity? Rapid Commun Mass Spectrom. 2007;21(5):653-60. PubMed PMID: 17279488.
5: Long JA, Harris NJ, Lammertsma K. Formaldehyde oxime <--> nitrosomethane tautomerism. J Org Chem. 2001 Oct 5;66(20):6762-7. PubMed PMID: 11578232.
6: Kearley GJ, Fillaux F, Baron MH, Bennington S, Tomkinson J. A new look at proton transfer dynamics along the hydrogen bonds in amides and peptides. Science. 1994 May 27;264(5163):1285-9. PubMed PMID: 17780844.
7: Ciarkowski J, Chen FM, Benoiton NL. Reaction mechanisms in peptide synthesis. Part 2. Tautomerism of the peptide bond. J Comput Aided Mol Des. 1991 Dec;5(6):599-616. PubMed PMID: 1818093.
8: Luzhnikov EA, Trushin AM, Kabanov OV. [Characteristics of barbiturate adsorption on activated charcoal]. Vopr Med Khim. 1987 Nov-Dec;33(6):64-6. Russian. PubMed PMID: 3445548.
9: McIlroy PJ, Richert ND, Ryan RJ. Effects of proteinase inhibitors on adenylate cyclase. Biochem J. 1980 May 15;188(2):423-35. PubMed PMID: 7396871; PubMed Central PMCID: PMC1161885.
