Scicinib | CAS#921768-26-5 | Hematological Cancer Treatment | Solid Tumor Treatment

MedKoo Cat#: 527414 | Name: Scicinib

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Scicinib is a bioactive chemical potentially used to treat hematological cancer and solid tumors.

Chemical Structure

Scicinib

CAS#921768-26-5

Theoretical Analysis

MedKoo Cat#: 527414

Name: Scicinib

CAS#: 921768-26-5

Chemical Formula: C13H14N4S2

Exact Mass: 290.0660

Molecular Weight: 290.40

Elemental Analysis: C, 53.77; H, 4.86; N, 19.29; S, 22.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Scicinib

IUPAC/Chemical Name

(Z)-N,N-dimethyl-2-(pyridin-2-yl(thiophen-2-yl)methylene)hydrazine-1-carbothioamide

InChi Key

ATVSBDLHTRCTLD-QINSGFPZSA-N

InChi Code

InChI=1S/C13H14N4S2/c1-17(2)13(18)16-15-12(11-7-5-9-19-11)10-6-3-4-8-14-10/h3-9H,1-2H3,(H,16,18)/b15-12-

SMILES Code

S=C(N/N=C(C1=NC=CC=C1)\C2=CC=CS2)N(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 290.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Scaini S, Belotti R, Ogliari A, Battaglia M. A comprehensive meta-analysis of cognitive-behavioral interventions for social anxiety disorder in children and adolescents. J Anxiety Disord. 2016 Aug;42:105-12. doi: 10.1016/j.janxdis.2016.05.008. Review. PubMed PMID: 27399932. 2: Lehmann LM, Santos PC, Scaini CJ. Evaluation of Pregnant and Postpartum Women's Knowledge about Toxoplasmosis in Rio Grande - RS, Brazil. Rev Bras Ginecol Obstet. 2016 Nov;38(11):538-544. doi: 10.1055/s-0036-1593970. PubMed PMID: 27907933. 3: Scaini G, Tonon T, de Souza CF, Schuk PF, Ferreira GC, Neto JS, Amorin T, Schwartz IV, Streck EL. Serum Markers of Neurodegeneration in Maple Syrup Urine Disease. Mol Neurobiol. 2016 Sep 22. [Epub ahead of print] Erratum in: Mol Neurobiol. 2016 Nov 4;:. PubMed PMID: 27660262. 4: Mattos GT, Santos PC, Telmo PL, Berne ME, Scaini CJ. Human Toxocariasis: Prevalence and Factors Associated with Biosafety in Research Laboratories. Am J Trop Med Hyg. 2016 Dec 7;95(6):1428-1431. PubMed PMID: 27698276; PubMed Central PMCID: PMC5154462. 5: Scaini G, Tonon T, de Souza CF, Schuck PF, Ferreira GC, Neto JS, Amorim T, Schwartz IV, Streck EL. Erratum to: Serum Markers of Neurodegeneration in Maple Syrup Urine Disease. Mol Neurobiol. 2016 Nov 4. [Epub ahead of print] PubMed PMID: 27815833. 6: Scaini G, Rezin GT, Carvalho AF, Streck EL, Berk M, Quevedo J. Mitochondrial dysfunction in bipolar disorder: Evidence, pathophysiology and translational implications. Neurosci Biobehav Rev. 2016 Sep;68:694-713. doi: 10.1016/j.neubiorev.2016.06.040. Review. PubMed PMID: 27377693. 7: Cadore PS, Zhang L, Lemos Lde L, Lorenzi C, Telmo Pde L, Dos Santos PC, Mattos GT, Vignol FS, Prietsch SO, Berne ME, Scaini CJ. Toxocariasis and childhood asthma: A case-control study. J Asthma. 2016 Aug;53(6):601-6. doi: 10.3109/02770903.2015.1064951. PubMed PMID: 27104477. 8: Scaini S, Belotti R, Ogliari A. Genetic and environmental contributions to social anxiety across different ages: a meta-analytic approach to twin data. J Anxiety Disord. 2014 Oct;28(7):650-6. doi: 10.1016/j.janxdis.2014.07.002. Review. PubMed PMID: 25118017. 9: Mata-Santos T, D'Oca Cda R, Mata-Santos HA, Fenalti J, Pinto N, Coelho T, Berne ME, da Silva PE, D'Oca MG, Scaini CJ. Toxocara canis: Larvicidal activity of fatty acid amides. Bioorg Med Chem Lett. 2016 Feb 1;26(3):739-41. doi: 10.1016/j.bmcl.2016.01.002. PubMed PMID: 26783180. 10: Santos PC, Lehmann LM, Lorenzi C, Hirsch C, Telmo PL, Mattos GT, Cadore PS, Klafke GB, Berne ME, Gonçalves CV, Scaini CJ. The Seropositivity of Toxocara spp. Antibodies in Pregnant Women Attented at the University Hospital in Southern Brazil and the Factors Associated with Infection. PLoS One. 2015 Jul 6;10(7):e0131058. doi: 10.1371/journal.pone.0131058. PubMed PMID: 26146833; PubMed Central PMCID: PMC4492739. 11: Mata-Santos T, Pinto NF, Mata-Santos HA, De Moura KG, Carneiro PF, Carvalho Tdos S, Del Rio KP, Pinto Mdo C, Martins LR, Fenalti JM, Da Silva PE, Scaini CJ. ANTHELMINTIC ACTIVITY OF LAPACHOL, β-LAPACHONE AND ITS DERIVATIVES AGAINST Toxocara canis LARVAE. Rev Inst Med Trop Sao Paulo. 2015 May-Jun;57(3):197-204. doi: 10.1590/S0036-46652015000300003. PubMed PMID: 26200958; PubMed Central PMCID: PMC4544242. 12: de Souza Aguiar P, Furtado RD, de Avila LF, de Lima Telmo P, Martins LH, Berne ME, da Silva PE, Scaini CJ. Transmammary infection in BALB/c mice with chronic toxocariasis. Parasitol Int. 2015 Apr;64(2):145-7. doi: 10.1016/j.parint.2014.04.010. PubMed PMID: 24837181. 13: Telmo Pde L, Avila LF, Santos CA, Aguiar Pde S, Martins LH, Berne ME, Scaini CJ. elevated trans-mammary transmission of Toxocara canis larvae in BALB/c mice. Rev Inst Med Trop Sao Paulo. 2015 Jan-Feb;57(1):85-7. doi: 10.1590/S0036-46652015000100013. PubMed PMID: 25651332; PubMed Central PMCID: PMC4325529. 14: Scaini G, Morais MO, Furlanetto CB, Kist LW, Pereira TC, Schuck PF, Ferreira GC, Pasquali MA, Gelain DP, Moreira JC, Bogo MR, Streck EL. Acute Administration of Branched-Chain Amino Acids Increases the Pro-BDNF/Total-BDNF Ratio in the Rat Brain. Neurochem Res. 2015 May;40(5):885-93. doi: 10.1007/s11064-015-1541-1. PubMed PMID: 25681161. 15: Scaini G, Morais MO, Galant LS, Vuolo F, Dall'Igna DM, Pasquali MA, Ramos VM, Gelain DP, Moreira JC, Schuck PF, Ferreira GC, Soriano FG, Dal-Pizzol F, Streck EL. Coadministration of branched-chain amino acids and lipopolysaccharide causes matrix metalloproteinase activation and blood-brain barrier breakdown. Mol Neurobiol. 2014 Oct;50(2):358-67. doi: 10.1007/s12035-013-8618-0. PubMed PMID: 24390570.