BGC201531 | GTPL3380 | AP-1531 | CAS#1186532-61-5 | EP4 antagonist

MedKoo Cat#: 531569 | Name: BGC201531

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BGC201531, also known as GTPL3380 and AP-1531, is a EP4 antagonist for the treatment of acute migraine.

Chemical Structure

BGC201531

CAS#1186532-61-5

Theoretical Analysis

MedKoo Cat#: 531569

Name: BGC201531

CAS#: 1186532-61-5

Chemical Formula: C26H28N2O6S

Exact Mass: 496.1668

Molecular Weight: 496.58

Elemental Analysis: C, 62.89; H, 5.68; N, 5.64; O, 19.33; S, 6.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

BGC201531; BGC-201531; BGC 201531; GTPL3380;GTPL-3380; GTPL 3380; AP-1531; AP1531; AP1531;

IUPAC/Chemical Name

4-[4-(5-methoxypyridin-2-yl)phenoxymethyl]-5-methyl-N-[(2-methylbenzene)sulfonyl]oxolane-2-carboxamide

InChi Key

BGXAOTTWXYPIQN-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H28N2O6S/c1-17-6-4-5-7-25(17)35(30,31)28-26(29)24-14-20(18(2)34-24)16-33-21-10-8-19(9-11-21)23-13-12-22(32-3)15-27-23/h4-13,15,18,20,24H,14,16H2,1-3H3,(H,28,29)

SMILES Code

O=C(NS(=O)(C1=CC=CC=C1C)=O)C2OC(C(C2)COC3=CC=C(C=C3)C4=NC=C(C=C4)OC)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 496.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Antonova M, Wienecke T, Maubach K, Thomas E, Olesen J, Ashina M. The pharmacological effect of BGC20-1531, a novel prostanoid EP4 receptor antagonist, in the prostaglandin E2 human model of headache. J Headache Pain. 2011 Oct;12(5):551-9. doi: 10.1007/s10194-011-0358-9. Epub 2011 Jun 17. PubMed PMID: 21681585; PubMed Central PMCID: PMC3173651. 2: Maubach KA, Davis RJ, Clark DE, Fenton G, Lockey PM, Clark KL, Oxford AW, Hagan RM, Routledge C, Coleman RA. BGC20-1531, a novel, potent and selective prostanoid EP receptor antagonist: a putative new treatment for migraine headache. Br J Pharmacol. 2009 Jan;156(2):316-27. doi: 10.1111/j.1476-5381.2009.00027.x. Epub 2009 Jan 19. PubMed PMID: 19154437; PubMed Central PMCID: PMC2697835. 3: Antonova M. Prostaglandins and prostaglandin receptor antagonism in migraine. Dan Med J. 2013 May;60(5):B4635. Review. PubMed PMID: 23673269.