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MedKoo Cat#: 531534 | Name: AZD4619

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD4619 is a potent, selective and reversible orally bioavailable PPARα receptor agonist.

Chemical Structure

AZD4619
AZD4619
CAS#1067247-60-2

Theoretical Analysis

MedKoo Cat#: 531534

Name: AZD4619

CAS#: 1067247-60-2

Chemical Formula: C27H30O6S2

Exact Mass: 514.1484

Molecular Weight: 514.65

Elemental Analysis: C, 63.01; H, 5.88; O, 18.65; S, 12.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AZD4619; AZ11942571; AZD 4619; AZD-4619.
IUPAC/Chemical Name
2-[2-(4-methylphenyl)ethylsulfanyl]-3-[4-[2-(4-methylsulfonyloxyphenoxy)ethyl]phenyl]propanoic acid
InChi Key
CIHMPKKTGUOBBS-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H30O6S2/c1-20-3-5-22(6-4-20)16-18-34-26(27(28)29)19-23-9-7-21(8-10-23)15-17-32-24-11-13-25(14-12-24)33-35(2,30)31/h3-14,26H,15-19H2,1-2H3,(H,28,29)
SMILES Code
O=C(O)C(SCCC1=CC=C(C)C=C1)CC2=CC=C(CCOC3=CC=C(OS(=O)(C)=O)C=C3)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 514.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Thulin P, Bamberg K, Buler M, Dahl B, Glinghammar B. The peroxisome proliferator-activated receptor α agonist, AZD4619, induces alanine aminotransferase-1 gene and protein expression in human, but not in rat hepatocytes: Correlation with serum ALT levels. Int J Mol Med. 2016 Sep;38(3):961-8. doi: 10.3892/ijmm.2016.2681. PubMed PMID: 27430334. 2: Thulin P, Rafter I, Stockling K, Tomkiewicz C, Norjavaara E, Aggerbeck M, Hellmold H, Ehrenborg E, Andersson U, Cotgreave I, Glinghammar B. PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes. Toxicol Appl Pharmacol. 2008 Aug 15;231(1):1-9. doi: 10.1016/j.taap.2008.03.007. PubMed PMID: 18455211.