AZD6538 is a mGluR5 negative allosteric modulator. AZD6538 selectively reduces mGluR5 signaling by modulating the receptor’s conformation, dampening excessive glutamatergic activity associated with various neurological and psychiatric disorders. AZD6538 has shown efficacy in reducing anxiety-like behaviors, seizures, and alcohol consumption in rodent models. Early-phase studies demonstrate its potential for treating Fragile X syndrome and anxiety, with generally favorable tolerability. AZD6538 exemplifies the therapeutic potential of mGluR5 NAMs, offering a promising approach for disorders linked to excessive glutamatergic activity.
MedKoo Cat#: 531545
Name: AZD6538
CAS#: 453566-30-8
Chemical Formula: C15H6FN5O
Exact Mass: 291.0556
Molecular Weight: 291.25
Elemental Analysis: C, 61.86; H, 2.08; F, 6.52; N, 24.05; O, 5.49
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.0 | 13.73 |
The following data is based on the product molecular weight 291.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
