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MedKoo Cat#: 531546 | Name: AZD-6605

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD6605 is a potent, reversible inhibitor of matrix metalloproteinases MMP13 (Collagenase 3), MMP2, MMP9 and MMP12.

Chemical Structure

AZD-6605
AZD-6605
CAS#893556-15-5

Theoretical Analysis

MedKoo Cat#: 531546

Name: AZD-6605

CAS#: 893556-15-5

Chemical Formula: C18H21F4N3O6S

Exact Mass: 483.1087

Molecular Weight: 483.44

Elemental Analysis: C, 44.72; H, 4.38; F, 15.72; N, 8.69; O, 19.86; S, 6.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AZD-6605; AZD 6605; AZD6605; AZ11920155; AZ-11920155.
IUPAC/Chemical Name
(5S)-5-methyl-5-[[4-[4-(1,1,2,2-tetrafluoroethoxy)phenoxy]piperidin-1-yl]sulfonylmethyl]imidazolidine-2,4-dione
InChi Key
SBVAXUGOISPYPX-QGZVFWFLSA-N
InChi Code
InChI=1S/C18H21F4N3O6S/c1-17(15(26)23-16(27)24-17)10-32(28,29)25-8-6-12(7-9-25)30-11-2-4-13(5-3-11)31-18(21,22)14(19)20/h2-5,12,14H,6-10H2,1H3,(H2,23,24,26,27)/t17-/m1/s1
SMILES Code
O=C1NC([C@](CS(=O)(N2CCC(OC3=CC=C(OC(F)(F)C(F)F)C=C3)CC2)=O)(C)N1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 483.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: De Savi C, Waterson D, Pape A, Lamont S, Hadley E, Mills M, Page KM, Bowyer J, Maciewicz RA. Hydantoin based inhibitors of MMP13--discovery of AZD6605. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4705-12. doi: 10.1016/j.bmcl.2013.05.089. PubMed PMID: 23810497.